SIGMAR1 抗体 (Middle Region)
Quick Overview for SIGMAR1 抗体 (Middle Region) (ABIN357897)
抗原
See all SIGMAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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特异性
- This antibody detects OPRS1 (Center).
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纯化方法
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human OPRS1.
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亚型
- Ig Fraction
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anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 47-81), (N-Term) antibody
SIGMAR1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB14256 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 21-120) antibodySIGMAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 112-169) antibodySIGMAR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 31-80) antibodySIGMAR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 118-147) antibodySIGMAR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB14335 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 113-126), (Intracellular) antibodyKO Validated SIGMAR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))
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别名
- SIGMAR1 / OPRS1
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背景
- The sigma (s) receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1) and its agonists are implicated in a variety of cellular functions, biological processes and diseases, including cancer biology, psychosis, regulation of neurotransmitter function, motor, endocrine and immune systems. Two sigma receptors, -1 and -2 are presently known and classified based on their ability to bind a variety of ligands. The sigma-1 receptor interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. It is distinct from any known receptor class and lacks significant homology to known mammalian proteins but possesses some homology with fungal sterol isomerases. The predicted structure of this 25 kDa protein depicts two transmembrane domains with both N- and C-terminal tails residing in the cytoplasm. The sigma-1 receptor is highly expressed in the central nervous system, heart, ovary, kidney, testes, liver, placenta and embryonic stem cells. Both sigma receptors are also highly expressed in tumor cell lines from various tissues, including small- and non-small-cell lung carcinoma, large-cell carcinoma, renal carcinoma, colon carcinoma, sarcoma, brain tumors, breast cancer, emlanoma, glioblastoma, neuroblastoma and prostate cancer. The exact mechanism how sigma-1R affects cancer biology is not known. Some hypotheses include modulation of ion channel activity, cytoskeletal proteins such as ankyrin, intracellular calcium levels, or sphingolipid levels1. Recent evidence also suggests that sigma-1R is important in the compartmentalization / transport of ER-synthesized lipids. Two polymorphisms of the sigma-1R gene, which decrease expression of the gene, are associated with occurrence of Alzheimer's disease.Synonyms: AAG8, Aging-associated gene 8 protein, SIG-1R, SR-BP, SR31747-binding protein, SRBP, Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1, Sigma1-receptor, Sigma1R
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分子量
- 25128 Da
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基因ID
- 10280, 9606
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UniProt
- Q99720
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途径
- SARS-CoV-2 Protein Interactome
抗原
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