SUMO4 抗体 (M55V)
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Quick Overview for SUMO4 抗体 (M55V) (ABIN356787)
抗原
See all SUMO4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- M55V
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特异性
- This antibody is specific to SUMO4 (V55 Mutant).
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纯化方法
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
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亚型
- Ig Fraction
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anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibody
SUMO4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (Mutant), (Val55) antibodySUMO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7264 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D3 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63) antibodySUMO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7262 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63), (Wild Type) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (M55V) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry on paraffin sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
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别名
- SUMO4 / SMT3H4
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背景
- SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.Synonyms: SUMO-4, Small ubiquitin-like protein 4, Small ubiquitin-related modifier 4
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基因ID
- 387082, 9606
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UniProt
- Q6EEV6
抗原
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