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Tyrosinase-Related Protein 1 抗体 (4th Cytoplasmic Loop)

This anti-Tyrosinase-Related Protein 1 antibody is a 兔 多克隆 antibody detecting Tyrosinase-Related Protein 1 in IHC 和 WB. Suitable for Drosophila melanogaster.
产品编号 ABIN351093
发货至: 中国

Quick Overview for Tyrosinase-Related Protein 1 抗体 (4th Cytoplasmic Loop) (ABIN351093)

抗原

See all Tyrosinase-Related Protein 1 (TYRP1) 抗体
Tyrosinase-Related Protein 1 (TYRP1)

适用

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Drosophila melanogaster

宿主

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克隆类型

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多克隆

标记

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This Tyrosinase-Related Protein 1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB)
  • 抗原表位

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    4th Cytoplasmic Loop

    原理

    Rabbit antibody to TRP

    特异性

    Specific for TRP.

    交叉反应

    Drosophila melanogaster

    交叉反应 (详细)

    Other species not yet tested.

    纯化方法

    IgG

    免疫原

    A synthetic peptide from 4th cytoplasmic loop of drosophila TRP (Transient receptor potential protein) conjugated to an immunogenic carrier protein was used as the antigen.

    亚型

    IgG
  • 应用备注

    IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

    注意事项

    Avoid freeze and thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

    有效期

    12 months
  • 抗原

    Tyrosinase-Related Protein 1 (TYRP1)

    别名

    TRP

    背景

    FUNCTION: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC thereby facilitating phosphatidylinositol 4 5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response though it is unclear whether as heteromultimers or as distinct units and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. SUBUNIT: The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC) inaC (PKC) and possibly trpl ninaC FKBP59 calmodulin and rhodopsin. Forms homomultimers and heteromultimers with trpl. Interaction with trpl is mediated in part by the N-terminal region and the transmembrane domains. Also interacts though to a lower extent with trp-gamma. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Note: Localized on plasma membrane loops found at the base of the rhabdomere in close proximity to the calcium stores. TISSUE SPECIFICITY: Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.

    UniProt

    P19334
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