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MUC1 抗体

This anti-MUC1 antibody is a 小鼠 单克隆 antibody detecting MUC1 in IHC, WB, FACS, IHC (p), ICC 和 IHC (fro). Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN335355
发货至: 中国

Quick Overview for MUC1 抗体 (ABIN335355)

抗原

See all MUC1 抗体
MUC1 (Mucin 1 (MUC1))

适用

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小鼠

克隆类型

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单克隆

标记

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This MUC1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

GP1-4
  • 特异性

    Human.

    纯化方法

    Prepared from rabbit serum by affinity purification on a column made with the peptide antigen.

    免疫原

    GP1.4 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with human milk fat globule.

    亚型

    IgG1
  • 应用备注

    GP1.4 reacts with all glycoforms of Episialin. APPLICATIONS GP1.4 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues, and flow cytometry. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for flow cytometry, and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.

    限制

    仅限研究用
  • 储存条件

    4 °C
  • Norum, Sauren, Rye, Nustad: "New immunoassays for MUC1 in breast cancer." in: Tumour biology, Vol. 22, Issue 4, pp. 216-22, (2001) (PubMed).

    Norum, Varaas, Kierulf, Nustad: "Carcinoma-associated MUC1 detected by immunoradiometric assays." in: Tumour biology, Vol. 19 Suppl 1, pp. 134-46, (1998) (PubMed).

    Gourevitch, von Mensdorff-Pouilly, Litvinov, Kenemans, van Kamp, Verstraeten, Hilgers: "Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients." in: British journal of cancer, Vol. 72, Issue 4, pp. 934-8, (1995) (PubMed).

  • 抗原

    MUC1 (Mucin 1 (MUC1))

    别名

    Episialin

    背景

    Episialin is also known as MUC1, MAM-6, CA 15-3, PEM and EMA. It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. The gene encoding episialin (MUC1) is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. Episialin is present in several secretory epithelial cell types

    途径

    Negative Regulation of intrinsic apoptotic Signaling
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