MDM4-binding Protein 抗体 (pSer367)
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Quick Overview for MDM4-binding Protein 抗体 (pSer367) (ABIN3201009)
抗原
See all MDM4-binding Protein (MDM4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer367
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产品特性
- Product: Mouse monoclonal antibody (clone #15) specific to the MdmX protein phosphorylated at Ser367, Human and mouse MdmX proteins phosphorylated at Ser367
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纯化方法
- Purified
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免疫原
- A synthetic peptide corresponding to a sequence of human Mdmx protein surrounding pSer367
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亚型
- IgG2b kappa
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anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibodyMDM4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Mdm4-binding Protein (MDM4) (pSer367) antibodyMDM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 130-179) antibodyMDM4 适用: 人, Cow, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (N-Term) antibodyMDM4 适用: 人, Cow, Pig, 兔, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 301-400) antibodyMDM4 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 208-306) antibodyMDM4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Western blotting: ~1 g/mL
2. Immunoprecipitation
3. ELISA
4. Indirect immuno-staining -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 50 % Glycerol
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储存液
- Azide free
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储存条件
- -20 °C/-80 °C
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储存方法
- -20 C (For long term storage: -70 C)
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: "ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage." in: The EMBO journal, Vol. 24, Issue 19, pp. 3411-22, (2005) (PubMed).
: "DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9608-20, (2005) (PubMed).
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: "ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage." in: The EMBO journal, Vol. 24, Issue 19, pp. 3411-22, (2005) (PubMed).
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- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
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别名
- Mdmx/Hdmx
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背景
- MdmX (synonyms: Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80- kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as a result, it binds to14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions.
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UniProt
- O15151
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途径
- Cell Division Cycle
抗原
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