MDM4-binding Protein 抗体 (N-Term)
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Quick Overview for MDM4-binding Protein 抗体 (N-Term) (ABIN2792185)
抗原
See all MDM4-binding Protein (MDM4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- MDM4 Antibody - N-terminal region
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序列
- IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA
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预测反应
- Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%
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产品特性
- This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4
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anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, FACS, IP 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, FACS, IP 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibodyMDM4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 130-179) antibodyMDM4 适用: 人, Cow, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (pSer367) antibodyMDM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (N-Term) antibodyMDM4 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." in: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).
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- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
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别名
- MDM4
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背景
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Background Information: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Name: Mdm4 p53 binding protein homolog (mouse)
Alternative Symbols: HDMX, MDMX, MRP1, BMFS6
Protein Name: Protein Mdm4
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分子量
- 55kDa
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基因ID
- 4194
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NCBI登录号
- NP_002384
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UniProt
- O15151
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途径
- Cell Division Cycle
抗原
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