DLL4 抗体 (Internal Region)
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Quick Overview for DLL4 抗体 (Internal Region) (ABIN318838)
抗原
See all DLL4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.
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纯化方法
- Purified
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免疫原
- Synthetic peptide corresponding to the internal region of human DLL4.
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亚型
- IgG
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anti-delta-Like 4 (DLL4) (AA 313-439) antibody
DLL4 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 215-331) antibodyDLL4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) (Internal Region) antibodyDLL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal 4A11F8-4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 44-345) antibodyDLL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) (AA 123-221) antibodyDLL4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibody (PE)DLL4 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal HMD4-2 PE
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应用备注
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Immunohistochemistry on paraffin sections: 5 - 15g/mL. ELISA: 1: 3000 - 1: 15000. Western Blot: 1: 300 - 1: 1500, detects a band of approximately 74 kDa in pancreatic celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0mg/mL
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缓冲液
- Phosphate buffered saline pH 7.2 containing 0.09 % Sodium Azide (NaN3)
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway." in: Mediators of inflammation, Vol. 2016, pp. 2853040, (2017) (PubMed).
: "Effects of canonical NF-κB signaling pathway on the proliferation and odonto/osteogenic differentiation of human stem cells from apical papilla." in: BioMed research international, Vol. 2014, pp. 319651, (2014) (PubMed).
: "Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway." in: Journal of molecular signaling, Vol. 7, Issue 1, pp. 14, (2012) (PubMed).
: "Identification of claudins by western blot and immunofluorescence in different cell lines and tissues." in: Methods in molecular biology (Clifton, N.J.), Vol. 762, pp. 213-31, (2011) (PubMed).
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: "GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway." in: Mediators of inflammation, Vol. 2016, pp. 2853040, (2017) (PubMed).
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- DLL4 (delta-Like 4 (DLL4))
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别名
- delta-Like Protein 4 / DLL4
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背景
- DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.Synonyms: Delta 4, Drosophila Delta homolog 4
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基因ID
- 54567
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NCBI登录号
- NP_061947
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UniProt
- Q9NR61
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途径
- Notch Signaling
抗原
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