EGFR 抗体 (AA 1189-1199)
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Quick Overview for EGFR 抗体 (AA 1189-1199) (ABIN318810)
抗原
See all EGFR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1189-1199
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特异性
- This antibody detects human epidermal growth factor receptor (EGFR).
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纯化方法
- Purified
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免疫原
- Synthetic peptide corresponding to amino acids 1189-1199 of human EGF receptor protein.
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亚型
- IgG
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应用备注
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ELISA: 1: 8000 - 1: 32000. Western Blot: 1: 500 - 1: 5000, detects a band of approximately 170 kDa in A431 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0mg/mL
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缓冲液
- Phosphate buffered saline pH 7.2 containing 0.01 % Sodium Azide (NaN3)
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- EGFR (Epidermal Growth Factor Receptor (EGFR))
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别名
- EGFR / ERBB1
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背景
- EGFR is a 170kD transmembrane glycoprotein which is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut. Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1
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基因ID
- 1956
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NCBI登录号
- NP_005219
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UniProt
- P00533
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途径
- NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
抗原
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