电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

BRCA2 抗体 (AA 2587-2601)

This anti-BRCA2 antibody is a 兔 多克隆 antibody detecting BRCA2 in IHC (fro). Suitable for 人, 大鼠, 小鼠, 猴, Cat, 犬 和 马.
产品编号 ABIN318412
发货至: 中国

Quick Overview for BRCA2 抗体 (AA 2587-2601) (ABIN318412)

抗原

See all BRCA2 抗体
BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

适用

人, 大鼠, 小鼠, 猴, Cat, 犬, 马

宿主

  • 41
  • 8

克隆类型

  • 40
  • 9
多克隆

标记

  • 39
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This BRCA2 antibody is un-conjugated

应用范围

  • 33
  • 17
  • 15
  • 11
  • 8
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2587-2601

    序列

    LIPSNDGKAG KEEFY

    特异性

    This antibody is specific for Breast Cancer Type 2 susceptibility protein (BRCA2), a tumour-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation. Based on sequence similarity, is expected to react with: Mouse, Rat, Horse, Cat, Chimpanzee, Rhesus Monkey and Dog.

    纯化方法

    Purified IgG prepared by affinity chromatography on Protein G

    免疫原

    Synthetic peptide corresponding to amino acids 2587-2601 of the human BRCA2 precursor, conjugated to Keyhole Limpet Haemocyanin.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections (1/25-1/100): This product requires antigenretrieval using heat treatment prior to staining of paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    5.0 mg/mL

    缓冲液

    Phosphate buffered saline containing 0.09 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

    别名

    BRCA2 / FANCD1

    背景

    BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25 % of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.Synonyms: Breast cancer type 2 susceptibility protein, FACD, Fanconi anemia group D1 protein

    基因ID

    675

    NCBI登录号

    NP_000050

    UniProt

    P51587

    途径

    DNA Damage Repair, M Phase, Maintenance of Protein Location
You are here:
Chat with us!