BRCA2 抗体 (AA 2587-2601)
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北京 101111
Quick Overview for BRCA2 抗体 (AA 2587-2601) (ABIN318412)
抗原
See all BRCA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2587-2601
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序列
- LIPSNDGKAG KEEFY
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特异性
- This antibody is specific for Breast Cancer Type 2 susceptibility protein (BRCA2), a tumour-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation. Based on sequence similarity, is expected to react with: Mouse, Rat, Horse, Cat, Chimpanzee, Rhesus Monkey and Dog.
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纯化方法
- Purified IgG prepared by affinity chromatography on Protein G
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免疫原
- Synthetic peptide corresponding to amino acids 2587-2601 of the human BRCA2 precursor, conjugated to Keyhole Limpet Haemocyanin.
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亚型
- IgG
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anti-Breast Cancer 2, Early Onset (BRCA2) (AA 21-130) antibody
BRCA2 适用: 人 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) antibodyBRCA2 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2990-3232) antibodyBRCA2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 1-300) antibodyBRCA2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 3319-3418) antibodyBRCA2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2913-3151) antibodyBRCA2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2308-2537) antibodyBRCA2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2737-2874) antibodyBRCA2 适用: 斑马鱼 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (pSer3291) antibodyBRCA2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 251-495) antibodyBRCA2 适用: 人 WB 宿主: 小鼠 Monoclonal 1643CT739-91-87 unconjugated
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应用备注
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Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections (1/25-1/100): This product requires antigenretrieval using heat treatment prior to staining of paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 5.0 mg/mL
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缓冲液
- Phosphate buffered saline containing 0.09 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
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别名
- BRCA2 / FANCD1
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背景
- BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25 % of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.Synonyms: Breast cancer type 2 susceptibility protein, FACD, Fanconi anemia group D1 protein
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基因ID
- 675
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NCBI登录号
- NP_000050
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UniProt
- P51587
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途径
- DNA Damage Repair, M Phase, Maintenance of Protein Location
抗原
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