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CREB1 抗体 (pSer133)

Name: CREB1 抗体 (pSer133)
SKU: ABIN318001
Availability: OutOfStock

This 兔多克隆 antibody specifically detects CREB1 in WB, IHC (p) 和 IP. It exhibits reactivity toward 人, 小鼠和大鼠.

Image no. 2 for anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody (ABIN318001) (CREB1 抗体 (pSer133))

Image no. 1 for anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody (ABIN318001) (CREB1 抗体 (pSer133))

2 images

产品编号 ABIN318001

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CREB1 抗体 (pSer133) (ABIN318001)

抗原

See all CREB1 抗体

CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CREB1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Discover our top product CREB1 Primary Antibody

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pSer133

特异性

This antibody detects endogenous levels of CREB pSer133 protein.

纯化方法

Affinity Chromatography using epitope-specific immunogen.
anti-cAMP Responsive Element Binding Protein 1 (CREB1) antibody
CREB1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 5G3 unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
CREB1 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer142) antibody
CREB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
CREB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-95) antibody
CREB1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 5F2 unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-341) antibody
CREB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F1-1B2 unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-341) antibody
CREB1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
CREB1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05198 unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (AA 105-132) antibody
CREB1 适用: 人, 小鼠, 大鼠 WB, IF, FACS 宿主: 兔 Polyclonal RB20652 unconjugated

anti-cAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
CREB1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 3C11 unconjugated Recombinant Antibody

应用备注

ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunoprecipitation: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1,0 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH ~7.2 with 15 mM Sodium Azide as preservative.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

别名

CREB1

背景

Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular CIS acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. Although CREB can bind to DNA in an unphosphorylated state, it cannot activate transcription. Phosphorylation of CREB on Ser 133 by protein kinase A facilitates its interaction with the 265 kDa CREB-binding protein (CBP) and activates the basal transcription complex. CREB functions in neoglucogenesis through interactions with the nuclear coactivator PGC-1. CREB may play a role in the pathogenesis of type II diabetes and dilated cardiomyopathy. The gene encoding CREB-1 maps to human chromosome 2q32.3-q34.Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1

分子量

approx. 38 kDa

基因ID

1385

NCBI登录号

NP_004370

UniProt

P16220

途径

TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation