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CD44 抗体

This anti-CD44 antibody is a 兔 多克隆 antibody detecting CD44 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN317946
发货至: 中国

Quick Overview for CD44 抗体 (ABIN317946)

抗原

See all CD44 抗体
CD44

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This CD44 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 特异性

    This antibody detects endogenous levels of CD44 protein.(region surrounding Glu702)

    纯化方法

    Affinity Chromatography using epitope-specific immunogen.
  • 应用备注

    ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    CD44

    别名

    CD44

    背景

    Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and play an important role in embryogenesis and development. HCAM (also designated CD44) is a member of the CAM family and participates in the progression of IgA nephropathy by binding hyaluronic acid and osteopontin. The colocalization of osteopontin in the bladder epithelium with αVβ3 integrin and HCAM suggests a role for HCAM in maintaining the integrity of the transitional epithelium by providing the sealing and adhesiveness needed for the impermeable state of the bladder. HCAM is closely related to the secretory phase of the normal menstrual cycle and its expression is decreased in hyperplasia and in cancer cases. Decreased HCAM expression may be functionally involved in the multiple mechanisms of the development and progression of endometrial lesions.Synonyms: CDw44, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein 1

    分子量

    approx. 90 kDa

    基因ID

    960

    NCBI登录号

    NP_000601

    UniProt

    P16070

    途径

    Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
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