MAPK6 抗体
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北京 101111
Quick Overview for MAPK6 抗体 (ABIN317885)
抗原
See all MAPK6 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ERK3 antibody detects endogenous levels of ERK3 protein.(region surrounding Lys185)
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纯化方法
- Affinity chromatography
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应用备注
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ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))
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别名
- MAPK6 / ERK3
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背景
- Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl2 and caspase 3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK3 gene maps to chromosome 15q21 and encodes a 721 amino acid protein.Synonyms: Extracellular signal-regulated kinase 3, MAP kinase isoform p97, Mitogen-activated protein kinase 6, Serine/threonine-protein kinase, p97-MAPK
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分子量
- approx. 83 kDa
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基因ID
- 5597
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NCBI登录号
- NP_002739
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UniProt
- Q16659
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
抗原
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