PAK4 抗体
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北京 101111
Quick Overview for PAK4 抗体 (ABIN317882)
抗原
See all PAK4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- PAK4/5/6 antibody detects endogenous levels of PAK4/5/6 protein.(region surrounding Val469)
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse and Rat.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-P21-Activated Kinase 4 (PAK4) (AA 299-542) antibody
PAK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 1-426) antibodyPAK4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (pSer474), (pSer560), (pSer602) antibodyPAK4 适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 2D1 unconjugated Recombinant Antibody
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 120-280) antibodyPAK4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 23-72) antibodyPAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 斑马鱼, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 156-187), (N-Term) antibodyPAK4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01233 unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 156-187) antibodyPAK4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/5000approx. 1/10000. Western Blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % Sodium Azide as preservative, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PAK4 (P21-Activated Kinase 4 (PAK4))
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别名
- PAK4
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背景
- Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.Synonyms: KIAA1142, KIAA1264, PAK 4, PAK-4, PAK-5, PAK-5, PAK-6, PAK-7, PAK5, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PAK 7, p21-activated kinase 4, p21-activated kinase 5, p21-activated kinase 6, p21-activated kinase 7
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分子量
- approx. 80 kDa
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基因ID
- 10298
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NCBI登录号
- NP_001014831
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UniProt
- O96013
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途径
- RTK signaling
抗原
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