FZD9 抗体
Our Local Distributor
北京 101111
Quick Overview for FZD9 抗体 (ABIN317735)
抗原
See all FZD9 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- Frizzled-9 antibody detects endogenous levels of Frizzled-9 protein.(region surrounding Leu591)
-
纯化方法
- Affinity-chromatography
-
-
-
-
应用备注
-
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1,0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- FZD9 (Frizzled Family Receptor 9 (FZD9))
-
别名
- CD349 / FZD9 / Frizzled-9
-
背景
- The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic β-catenin accumulation. In rat, frizzled-9 is important in Wnt/β-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.Synonyms: Fz-9, hFz9
-
分子量
- approx. 64 kDa
-
基因ID
- 8326
-
NCBI登录号
- NP_003499
-
UniProt
- O00144
-
途径
- WNT signaling
抗原
-