IRAK3 抗体
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北京 101111
Quick Overview for IRAK3 抗体 (ABIN317722)
抗原
See all IRAK3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of IRAK-M protein.(region surrounding Gln649)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity-Chromatography using epitope-specific immunogen.
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anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 454-596) antibody
IRAK3 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 6G9G2 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 497-596) antibodyIRAK3 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 1-596) antibodyIRAK3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C9 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (Internal Region) antibodyVerified IRAK3 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibodyKD Validated IRAK3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB875 unconjugated Recombinant Antibody
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibodyIRAK3 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 497-596) antibodyIRAK3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 1-596) antibodyIRAK3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 45-77), (N-Term) antibodyIRAK3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2344 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 491-540) antibodyIRAK3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))
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别名
- IRAK3
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背景
- Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. A 100 kDa IL-1- dependent kinase termed IRAK-1 (for IL-1 receptor- associated kinase 1) coimmunoprecipitates with activated IL-1RI and is implicated as an upstream mediator of NFκB activation. A related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB. IRAK-2 is a proximal mediator of IL1, a component of the IL1R signaling complex, and is required for IL1R-induced NFκB activation. IRAK-4, like IRAK-1 and Pelle, has auto- and cross-phosphorylation kinase activity. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells. IRAK-M mRNA transcripts are found predominantly in PBL and the monocytic cell lines U937 and THP-1.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
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分子量
- approx. 68 kDa
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基因ID
- 11213
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NCBI登录号
- NP_001135995
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UniProt
- Q9Y616
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途径
- TLR signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
抗原
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