PTH1R 抗体
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北京 101111
Quick Overview for PTH1R 抗体 (ABIN317698)
抗原
See all PTH1R 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PTH/PTHrP-R protein.(region surrounding Leu187)
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交叉反应 (详细)
- Species reactivity (tested):Human, Mouse and Rat.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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应用备注
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ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))
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别名
- PTH Receptor 1
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背景
- Parathyroid Hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by raising blood levels of calcium through various mechanisms. PTH stimulates bone formation to increase bone mass and strength in rats and humans. Within the PTH molecule, the essential activity is associated with the first 34 amino acids at the amino-terminus of the molecule. The gene encoding PTH maps to human chromosome 11p15.3-p15.1. Parathyroid hormone-related protein (PTH-rP) is an autocrine factor that is structurally related to PTH yet, unlike PTH, which is synthesized only by the parathyroid cells, PTH-rP is synthesized by several cell types. PTH-rP regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Isolated from the culture medium of a human lung cancer cell line, PTH-rP produces PTH-like effects that are characterized as humoral hypercalcemia of malignancy.Synonyms: PTH/PTHrP type I receptor, PTH1R, PTHR, PTHR1, Parathyroid hormone 1 receptor, Parathyroid hormone/parathyroid hormone-related peptide receptor
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分子量
- approx. 52 kDa
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基因ID
- 5745
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NCBI登录号
- NP_000307
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UniProt
- Q03431
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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