PTH1R 抗体 (1st Extracellular Loop)
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Quick Overview for PTH1R 抗体 (1st Extracellular Loop) (ABIN7887003)
抗原
See all PTH1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 1st Extracellular Loop, AA 241-255
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原理
- A Rabbit Polyclonal Antibody to Parathyroid Hormone 1 Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
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产品特性
- Anti-PTH1R (extracellular) Antibody (ABIN7043429, ABIN7045112 and ABIN7045113) is a highly specific antibody directed against an epitope of the rat Parathyroid hormone 1 receptor. The antibody can be used in western blot, immunohistochemistry, and live cell imaging applications. It has been designed to recognize PTH1R from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DAVLYSGFTLDEAER, corresponding to amino acid residues 241-255 of rat PTH1R
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亚型
- IgG
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anti-Parathyroid Hormone 1 Receptor (PTH1R) (pThr1) antibody
PTH1R 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) antibodyPTH1R 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (AA 27-134) antibodyPTH1R 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) antibodyPTH1R 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (AA 146-169) antibodyPTH1R 适用: 人, 小鼠, Cow, Pig, 犬, 猴, 马 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (AA 485-593) antibodyPTH1R 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (N-Term) antibodyPTH1R 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) antibodyPTH1R 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (AA 388-406), (C-Term) antibodyPTH1R 适用: 人, 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Parathyroid Hormone 1 Receptor (PTH1R) (AA 28-188) antibodyPTH1R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: 1:60
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IFC
Negative Control: (ABIN7236233)
Blocking Peptide: (ABIN7236233)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))
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别名
- PTH1R
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背景
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Synonyms: Parathyroid hormone 1 receptor, PTH/PTHrP type I receptor, PTH1 receptor, PTHR, PTHR1
Description: The parathyroid hormone receptor type 1 (PTHR1) is bound and activated by two peptide hormones: the parathyroid hormone (PTH) secreted by the parathyroid gland and by parathyroid hormone related peptide (PTHrP) which is produced locally in many tissues. Although these two peptides bind the same receptor, they exert different actions. PTH regulates the concentrations of Ca2+, phosphate ions and vitamin D in the blood, stimulates bone formation/resorption and is distributed to the kidneys where it regulates Ca2+ and phosphate transport, and is also detected in the liver1-3. PTHrP, on the other hand, plays a critical role early in development of bone, heart, mammary glands and other tissues, and is detected in the circulation only during lactation and secreted by some tumors1,2,4,5. PTHR1 is obviously localized to all areas and tissues where PTH and PTHrP are known to exert their effects (i.e. bone, kidney, blood, heart, etc.).PTHR1 belongs to the superfamily of G-protein coupled receptors. Like all members, PTHR1 has seven transmembrane spanning domains, an extracellular N-terminus and an intracellular C-terminal tail. Upon activation, the receptor couples to either Gs and Gq thereby activating adenylate cyclase and phospholipase C (PLC) respectively. In osteosarcoma cells, PTHR1 can also couple Gα2,6,7.PTH is being used today to treat osteoporosis, as a factor promoting bone formation. Mutations in PTHR1 are associated with Jansen's disease (hypercalcemia and dwarfism) and Eiken syndrome (cartilage tumors of bone)2,8-10.
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基因ID
- 56813
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NCBI登录号
- NM_000316
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UniProt
- P25961
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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