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TACC3 抗体

The 兔 多克隆 anti-TACC3 antibody (ABIN317622) specifically detects TACC3 in WB, IF 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN317622
发货至: 中国
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Quick Overview for TACC3 抗体 (ABIN317622)

抗原

See all TACC3 抗体
TACC3 (Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This TACC3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody detects endogenous levels of TACC3 protein.(region surrounding Thr813)

    纯化方法

    Affinity Chromatography using epitope-specific immunogen.
  • 应用备注

    ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    TACC3 (Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3))

    别名

    TACC3 / ERIC1

    背景

    TACC1 (transforming acidic coiled coil gene 1) is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15 % of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.Synonyms: ERIC-1, Transforming acidic coiled-coil-containing protein 3

    基因ID

    10460

    NCBI登录号

    NP_006333

    UniProt

    Q9Y6A5

    途径

    Maintenance of Protein Location
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