C3 抗体
Quick Overview for C3 抗体 (ABIN317012)
抗原
See all C3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- AM05608PU-N Recognises 42 kDa inactive complement component 3b (iC3b) neoantigen present in blood serum.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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产品特性
- Synonyms: CPAMD1, Complement component 3, C3 and PZP-like alpha-2-macroglobulindomain-containing protein 1
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纯化方法
- Purified IgG prepared by affinity chromatography on Protein A
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免疫原
- Purified Human iC3b
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亚型
- IgG2b
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anti-Complement Component 3 (C3) (AA 1000-1326) antibody
C3 适用: 人 WB, IHC, IP, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1551-1663) antibodyC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (fro), IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1644) antibodyC3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) (C-Term) antibodyC3 适用: 人 WB, IP, ICC, IF, IHC (p), ISub 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 23-300) antibodyC3 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 965-1303) antibodyC3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1645) antibodyC3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) antibodyC3 适用: 小鼠 WB, IP, FACS, IF, IA 宿主: 大鼠 Monoclonal 11H9 unconjugated
anti-Complement Component 3 (C3) (AA 966-1313) antibodyC3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1353-1382) antibodyC3 适用: 人 WB 宿主: 小鼠 Monoclonal 567CT11-2-3 unconjugated
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应用备注
- ELISA. Western blot. Flow cytometry. Immunohistochemistry on Frozen Sections. Histology Positive Control Tissue: Kidney from post streptoccal glomerulonephritispatients.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Borate buffered saline pH 8.2-8.4, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- C3 (Complement Component 3 (C3))
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别名
- Complement C3
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背景
- Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3
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基因ID
- 718
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UniProt
- P01024
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途径
- Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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