Retinoblastoma Protein (Rb) 抗体
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Quick Overview for Retinoblastoma Protein (Rb) 抗体 (ABIN306637)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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亚型
- IgG1
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限制
- 仅限研究用
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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别名
- Rb (Retinoblastoma)
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背景
- The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes. Synonyms: Retinoblastoma-associated protein, pRb, pp110, p105-Rb.
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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