Retinoblastoma Protein (Rb) 抗体
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- 抗原 See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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适用
- 人, 小鼠, 大鼠, 小鸡, Mink
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Retinoblastoma Protein (Rb) antibody is un-conjugated
- 应用范围
- 请咨询
- 克隆位点
- XZ91
- 亚型
- IgG1
- Top Product
- Discover our top product Rb Protein Primary Antibody
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- 限制
- 仅限研究用
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- 抗原
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
- 别名
- Rb (Retinoblastoma) (Rb Protein 产品)
- 背景
- The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes. Synonyms: Retinoblastoma-associated protein, pRb, pp110, p105-Rb.
- UniProt
- P06400
- 途径
- Mitotic G1-G1/S Phases
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