Retinoblastoma Protein (Rb) 抗体 (pSer811)
-
- 抗原 See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
-
抗原表位
- pSer811
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This Retinoblastoma Protein (Rb) antibody is un-conjugated
-
应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Dot Blot (DB)
- 交叉反应 （详细）
- Expected species reactivity: Mouse, Rat
- 纯化方法
- Antigen affinity purified
- 免疫原
- This p-Rb1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS811 of human Retinoblastoma.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product Rb Protein Primary Antibody
-
anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibody
Rb Protein 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibodyRb Protein 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibodyRb Protein 适用: 人, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal 172C1094 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer608) antibodyRb Protein 适用: 人 ELISA, IHC, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibodyRb Protein 适用: 人 ELISA, IHC, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibodyRb Protein 适用: 人 ELISA, IHC, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) antibodyRb Protein 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 7E4B8 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibodyRb Protein 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴, Pig, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (N-Term) antibodyRb Protein 适用: 人, 小鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibodyRb Protein 适用: 人, Cow, 犬, Pig, Bat, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Titration of the p-Rb1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the p-Rb1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
- 抗原
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
- 别名
- Retinoblastoma / Rb (Rb Protein 产品)
- 背景
- Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of Rb1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a p-Rb1/HDAC1 repressor complex. Upon calcium influx, Rb1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of Rb1/E2F1 complex thereby disrupting Rb1's activity. [UniProt]
- UniProt
- P06400
- 途径
- Mitotic G1-G1/S Phases
-
