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Retinoblastoma Protein (Rb) 抗体 (pSer807)

The 兔多克隆 anti-Retinoblastoma Protein (Rb) antibody is suitable to detect Retinoblastoma Protein (Rb) in samples from 人, 小鼠和大鼠. It has been validated for WB, IHC, IF 和 ICC.

Western blot analysis of lysates from K562 cells, using Phospho-Retinoblastoma (Ser807) Antibody at 1/1000 dilution. (Retinoblastoma Protein (Rb) 抗体 (pSer807))

IF/ICC

IHC (p)

3 images

产品编号 ABIN6256428

发货至: 中国

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Quick Overview for Retinoblastoma Protein (Rb) 抗体 (pSer807) (ABIN6256428)

抗原

See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体

Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Retinoblastoma Protein (Rb) antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product Rb Protein Primary Antibody

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pSer807

原理

Phospho-Retinoblastoma (Ser807) Antibody

特异性

Phospho-Retinoblastoma (Ser807) Antibody detects endogenous levels of Retinoblastoma only when phosphorylated at Serine 807.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser807.

亚型

IgG
anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibody
Rb Protein 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibody
Rb Protein 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer811) antibody
Rb Protein 适用: 人 IHC, ELISA, IF, DB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibody
Rb Protein 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibody
KD Validated Rb Protein 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3375 unconjugated Recombinant Antibody

anti-Retinoblastoma Protein (Rb Protein) (pSer807) antibody
KD Validated Rb Protein 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3245 unconjugated Recombinant Antibody

anti-Retinoblastoma Protein (Rb Protein) (pThr826) antibody
Rb Protein 适用: 人, 小鼠, 大鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibody
Rb Protein 适用: 人, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal 172C1094 unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer795) antibody
Rb Protein 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibody
Rb Protein 适用: 人 IHC, ELISA, DB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

别名

Retinoblastoma

背景

Description: Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Gene: RB1

分子量

106kDa

基因ID

5925

UniProt

P06400

途径

Mitotic G1-G1/S Phases