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PAK3 抗体 (N-Term)

This anti-PAK3 antibody is a 兔 多克隆 antibody detecting PAK3 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3044532
发货至: 中国

Quick Overview for PAK3 抗体 (N-Term) (ABIN3044532)

抗原

See all PAK3 抗体
PAK3

适用

  • 78
  • 31
  • 20
  • 3
人, 小鼠, 大鼠

宿主

  • 72
  • 5
  • 2

克隆类型

  • 71
  • 9
多克隆

标记

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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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This PAK3 antibody is un-conjugated

应用范围

  • 60
  • 38
  • 31
  • 13
  • 13
  • 9
  • 7
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)
  • 抗原表位

    • 17
    • 8
    • 8
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    • 3
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    • 2
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    • 2
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    • 1
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    AA 13-49, N-Term

    原理

    Anti-PAK3 Antibody Picoband®

    序列

    APPLRMNSNN RDSSALNHSS KPLPMAPEEK NKKARLR

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-PAK3 Antibody Picoband® (ABIN3044532). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human PAK3, identical to the related mouse and rat sequences.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
    1. "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". 2. Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (Oct 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nat Genet 20 (1): 25-30. 3. Donnelly AJ, Partington MW, Ryan AK, Mulley JC (Nov 1996). "Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)". Am J Med Genet 64 (1): 113-20.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    PAK3

    别名

    PAK3

    背景

    Synonyms: Serine/threonine-protein kinase PAK 3,2.7.11.1,Beta-PAK,Oligophrenin-3,p21-activated kinase 3,PAK-3,PAK3,OPHN3,

    Tissue Specificity: Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

    Background: Serine/threonine-protein kinase PAK 3?is an?enzyme?that in humans is encoded by the?PAK3?gene. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

    分子量

    62 kDa

    基因ID

    5063

    UniProt

    O75914
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