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FcRn 抗体 (AA 56-291)

Name: FcRn 抗体 (AA 56-291)
SKU: ABIN3044521
Availability: OutOfStock

FcRn 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of FCGRT expression in A549 whole cell lysates (lane 1). (FcRn 抗体 (AA 56-291))

FCGRT was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- FCGRT Antigen Affinity purified polyclonal antibody at 1 μg/mL. (FcRn 抗体 (AA 56-291))

IHC (p)

2 images

产品编号 ABIN3044521

发货至: 中国

Datasheet as PDF

抗原 See all FcRn 抗体

FcRn (neonatal Fc Receptor (FcRn))
抗原表位
13

10

6

3

2

1

1

1

1

1

1
AA 56-291
适用
41

5

4

1

1

1

1

1
人
宿主
39

7

1

1
兔
Compatible Secondaries
克隆类型
39

8

1
多克隆
标记
24

5

5

5

2

1

1

1

1

1

1

1
This FcRn antibody is un-conjugated
应用范围
27

26

8

5

4

2

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-FCGRT Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-FCGRT Antibody Picoband® (ABIN3044521). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E. coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2% and 68.9% amino acid (aa) sequence identity with mouse and rat FCGRT, respectively.

亚型

IgG

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FcRn 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315-22. 2. Junghans, R. P., Ebralidze, A., Tiwari, B. Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy? A new hypothesis of long-range cis autosomal inactivation. Neurogenetics 3: 59-67, 2001. 3. Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. 73 (1-2): 97-8.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

FcRn (neonatal Fc Receptor (FcRn))

别名

FCGRT (FcRn 产品)

背景

Synonyms: IgG receptor FcRn large subunit p51,FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,FCGRT,FCRN,
Tissue Specificity: Ubiquitous. Prominent expression in brain, lung, and liver. .
Background: IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

分子量

50 kDa

基因ID

2217

UniProt

P55899

途径

Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process