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Caspase 10 抗体 (N-Term)

Name: Caspase 10 抗体 (N-Term)
SKU: ABIN3044426
Availability: OutOfStock

CASP10 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated

Anti-Caspase-10 antibody, Western blotting Lane 1: COLO320 Cell Lysate Lane 2: HELA Cell Lysate Lane 3: SW620 Cell Lysate Lane 4: RAJI Cell Lysate (Caspase 10 抗体 (N-Term))

Anti-Caspase-10 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue (Caspase 10 抗体 (N-Term))

IHC

2 images

(1 reference)

产品编号 ABIN3044426

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 10 (CASP10) 抗体

Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))
抗原表位
15

5

4

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 220-236, N-Term
适用
67

14

4
人
宿主
58

5

2

1

1
兔
Compatible Secondaries
克隆类型
53

14
多克隆
标记
36

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This Caspase 10 antibody is un-conjugated
应用范围
34

20

16

13

12

12

10

10

9

4

3

2

1
Western Blotting (WB), Flow Cytometry (FACS)

原理

Anti-Caspase-10/CASP10 Antibody Picoband®

序列

VKTFLEALPR AAVYRMN

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Caspase-10/CASP10 Antibody (ABIN3044426). Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human CASP10.

亚型

IgG

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anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 223-459) antibody
CASP10 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) antibody
CASP10 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-110) antibody
CASP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E7 unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-110) antibody
CASP10 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 19-187) antibody
CASP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C9 unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) antibody
CASP10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (C-Term) antibody
CASP10 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 220-236) antibody
CASP10 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 431-521) antibody
CASP10 适用: 人 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 164-192) antibody
CASP10 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Lee, H.-J., Pyo, J.-O., Oh, Y., Kim, H.-J., Hong, S., Jeon, Y.-J., Kim, H., Cho, D.-H., Woo, H.-N., Song, S., Nam, J.-H., Kim, H. J., Kim, K.-S., Jung, Y.-K.AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.Nature Cell Biol. 9: 1303-1310, 2007. 2. Park, W. S., Lee, J. H., Shin, M. S., Park, J. Y., Kim, H. S., Lee, J. H., Kim, Y. S., Lee, S. N., Xiao, W., Park, C. H., Lee, S. H., Yoo, N. J., Lee, J. Y.Inactivating mutations of the caspase-10 gene in gastric cancer.Oncogene 21: 2919-2925, 2002. 3. Wang, J., Zheng, L., Lobito, A., Chan, F. K., Dale, J., Sneller, M., Yao, X., Puck, J. M., Straus, S. E., Lenardo, M. J.Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.Cell 98: 47-58, 1999.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Chen, Shu, Peng, Fang, Cui, Chen, Wang, Chen, Zuo, Deng, Geng, Lai: "Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B?." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 59, pp. 446-54, (2013) (PubMed).
抗原

Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

别名

CASP10 (CASP10 产品)

背景

Synonyms: Caspase-10,CASP-10,3.4.22.63,Apoptotic protease Mch-4,FAS-associated death domain protein interleukin-1B-converting enzyme 2,FLICE2,ICE-like apoptotic protease 4,Caspase-10 subunit p23/17,Caspase-10 subunit p12,CASP10,MCH4,
Tissue Specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Background: Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. The Caspase 10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere ion.This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Sequence Similarities: Belongs to the peptidase C14A family.

分子量

57 kDa

UniProt

Q92851

途径

Apoptosis, Caspase Cascade in Apoptosis