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CD40 Ligand 抗体 (N-Term)

Cited in 1 publication. This 兔 多克隆 anti-CD40 Ligand antibody specifically detects CD40 Ligand in WB 和 IHC. The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN3044319
发货至: 中国
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Quick Overview for CD40 Ligand 抗体 (N-Term) (ABIN3044319)

抗原

See all CD40 Ligand (CD40LG) 抗体
CD40 Ligand (CD40LG)

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This CD40 Ligand antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    AA 47-65, N-Term

    原理

    Anti-CD40L/CD40LG Antibody

    序列

    HRRLDKIEDE RNLHEDFVF

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-CD40L/CD40LG Antibody (ABIN3044319). Tested in IHC, WB applications. This antibody reacts with Human, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L, different from the related mouse sequence by three amino acids, rat sequence by four amino acids.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yang, Fang, Liu, Zhang, Shi, Ji, Lin, Lin: "Protective effects of chinese traditional medicine buyang huanwu decoction on myocardial injury." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 930324, (2012) (PubMed).

  • 抗原

    CD40 Ligand (CD40LG)

    别名

    CD40LG

    背景

    Synonyms: CD40 ligand,CD40-L,T-cell antigen Gp39,TNF-related activation protein,TRAP,Tumor necrosis factor ligand superfamily member 5,CD154,CD40 ligand, membrane form,CD40 ligand, soluble form,CD40LG,CD40L, TNFSF5, TRAP,

    Tissue Specificity: Specifically expressed on activated CD4+ T- lymphocytes.

    Background: CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

    Sequence Similarities: Belongs to the tumor necrosis factor family.

    分子量

    29 kDa

    UniProt

    P29965

    途径

    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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