CD40 Ligand 抗体 (N-Term)
(1 reference)Quick Overview for CD40 Ligand 抗体 (N-Term) (ABIN3044319)
抗原
See all CD40 Ligand (CD40LG) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 47-65, N-Term
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原理
- Anti-CD40L/CD40LG Antibody Picoband®
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序列
- HRRLDKIEDE RNLHEDFVF
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-CD40L/CD40LG Antibody (ABIN3044319). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L, different from the related mouse sequence by three amino acids, rat sequence by four amino acids.
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亚型
- IgG
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anti-CD40 Ligand (CD40LG) (AA 1-261) antibody
CD40LG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) (AA 108-261) antibodyCD40LG 适用: 人 FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal CD40LG-2763 unconjugated
anti-CD40 Ligand (CD40LG) (AA 108-261) antibodyCD40LG 适用: 人 FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal CD40LG-2761 unconjugated
anti-CD40 Ligand (CD40LG) antibody (FITC)CD40LG 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal MR-1 FITC
anti-CD40 Ligand (CD40LG) (AA 79-129) antibodyCD40LG 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) (AA 33-62) antibodyCD40LG 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) (AA 111-261) antibodyCD40LG 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) antibody (PE)CD40LG 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 24-31 PE
anti-CD40 Ligand (CD40LG) (AA 47-261) antibodyCD40LG 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8H10F5 unconjugated
anti-CD40 Ligand (CD40LG) (AA 47-261) antibodyCD40LG 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5A3A9 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
1. Allen,R.C.,Armitage,R.J.,Conley,M.E.,Rosenblatt,H.,Jenkins,N.A.,Copeland,N.G.,Bedell, M.A.,Edelhoff,S.,Disteche,C.M.,Simoneaux,D.K.,Fanslow,W.C.,Belmont,J.,Spriggs,M.K.:CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259: 990-993, 1993. 2. Cipollone,F.,Ferri,C.,Desideri,G.,Paloscia,L.,Materazzo,G.,Mascellanti,M.,Fazia,M., Iezzi,A.,Cuccurullo,C.,Pini,B.,Bucci,M.,Santucci,A.,Cuccurullo,F.,Mezzetti,A.:Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty. Circulation 108: 2776-2782, 2003. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Protective effects of chinese traditional medicine buyang huanwu decoction on myocardial injury." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 930324, (2012) (PubMed).
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: "Protective effects of chinese traditional medicine buyang huanwu decoction on myocardial injury." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 930324, (2012) (PubMed).
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- CD40 Ligand (CD40LG)
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别名
- CD40LG
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背景
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Synonyms: CD40 ligand,CD40-L,T-cell antigen Gp39,TNF-related activation protein,TRAP,Tumor necrosis factor ligand superfamily member 5,CD154,CD40 ligand, membrane form,CD40 ligand, soluble form,CD40LG,CD40L, TNFSF5, TRAP,
Tissue Specificity: Specifically expressed on activated CD4+ T- lymphocytes.
Background: CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.
Sequence Similarities: Belongs to the tumor necrosis factor family.
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分子量
- 29 kDa
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UniProt
- P29965
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途径
- NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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