FGF21 抗体 (N-Term)
Quick Overview for FGF21 抗体 (N-Term) (ABIN3044256)
抗原
See all FGF21 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 43-58, N-Term
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原理
- Anti-Fibroblast growth factor 21 FGF21 Antibody Picoband®
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序列
- QVRQRYLYTD DAQQTE
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Fibroblast growth factor 21 FGF21 Antibody (ABIN3044256). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human FGF21, different from the related rat and mouse sequences by two amino acids.
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亚型
- IgG
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anti-Fibroblast Growth Factor 21 (FGF21) (AA 30-209) antibody
FGF21 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F11 unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) antibodyFGF21 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (AA 30-209) antibodyFGF21 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (AA 29-209) antibodyFGF21 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (AA 29-209) antibodyFGF21 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (Internal Region) antibodyVerified FGF21 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (N-Term) antibodyFGF21 适用: 人, 小鼠, 大鼠, Pig, 猴, Cow, 犬, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (AA 29-120) antibodyFGF21 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) (AA 29-209) antibodyFGF21 适用: 人 FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor 21 (FGF21) antibodyFGF21 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Galman, C., Lundasen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafstrom, I., Dahlin, M., Amark, P., Angelin, B., Rudling, M. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR-alpha activation in man. Cell Metab. 8: 169-174, 2008. 2. Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Igelsias, R., Villarroya, F. Hepatic FGF21 expression is induced at birth via PPAR-alpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11: 206-212, 2010. 3. Nishimura, T., Nakatake, Y., Konishi, M., Itoh, N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta 1492: 203-206, 2000. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- FGF21 (Fibroblast Growth Factor 21 (FGF21))
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别名
- FGF21
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背景
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Synonyms: Fibroblast growth factor 21,FGF-21,FGF21,UNQ3115/PRO10196,
Background: FGF21 (Fibroblast growth factor 21) is a protein that in humans is encoded by the FGF21 gene, which is also a member of the fibroblast growth factor (FGF) family. The FGF21 gene is mapped on 19q13.33. Using RT-PCR, Fgf21 was expressed in several types of adipose tissue in mice, including subcutaneous and epididymal fat pads and brown adipose tissue. The level of Fgf21 expression in adipose tissue was comparable to that in liver. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Changes in Fgf21 expression due to suckling or nutritional manipulations were associated with changes in circulating free fatty acid and ketone body levels. In differentiated mouse brown adipocytes in culture, Fgf21 treatment increased the expression of thermogenic genes, caused higher total and uncoupled respiration, and enhanced glucose oxidation.
Sequence Similarities: Belongs to the heparin-binding growth factors family.
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分子量
- 21 kDa
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途径
- RTK signaling
抗原
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