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Lamin B2 抗体 (C-Term)

LMNB2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044232
发货至: 中国
  • 抗原 See all Lamin B2 (LMNB2) 抗体
    Lamin B2 (LMNB2)
    抗原表位
    • 14
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 580-597, C-Term
    适用
    • 56
    • 38
    • 19
    • 9
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 53
    • 18
    克隆类型
    • 49
    • 22
    多克隆
    标记
    • 41
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Lamin B2 antibody is un-conjugated
    应用范围
    • 52
    • 18
    • 18
    • 15
    • 12
    • 12
    • 10
    • 8
    • 8
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    原理
    Anti-Lamin B2/LMNB2 Antibody Picoband®
    序列
    EEDLFHQQGD PRTTSRGC
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-Lamin B2/LMNB2 Antibody (ABIN3044232). Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B2, identical to the related rat and mouse sequences.
    亚型
    IgG
    Top Product
    Discover our top product LMNB2 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat
    1. Biamonti, G., Giacca, M., Perini, G., Contreas, G., Zentilin, L., Weighardt, F., Guerra, M., Della Valle, G., Saccone, S., Riva, S., Falaschi, A. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. Molec. Cell. Biol. 2. Giacca, M., Zentilin, L., Norio, P., Diviacco, S., Dimitrova, D., Contreas, G., Biamonti, G., Perini, G., Weighardt, F., Riva, S., Falaschi, A. Fine mapping of a replication origin of human DNA. Proc. Nat. Acad. Sci. 91: 7119-7123, 1994.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.01 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Chen, Jiang, Gu, Lai, Liu, Zhang: "Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway." in: Environmental toxicology, Vol. 32, Issue 8, pp. 2004-2020, (2017) (PubMed).

  • 抗原
    Lamin B2 (LMNB2)
    别名
    LMNB2 (LMNB2 产品)
    背景

    Synonyms: Lamin-B2,LMNB2,LMN2,

    Tissue Specificity: Lung, testis and peripheral blood mononuclear cells.

    Background: Lamin B2, also called LMNB2, is a protein associated with laminopathies. The LMNB2 gene is mapped to the G-negative subtelomeric band p13.3 of chromosome 19 by in situ hybridization. The LMNB2 gene contains 12 exons. < a href="https://www.bosterbio.com/blog/post/how-to-choose-a-model-organism" style="color:#EA8D28">Common model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2, is generated as part of the International Knockout Mouse Consortium program-a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. A highly sensitive procedure about mapping the start site of DNA replication in a 13.7-kb region of human chromosome 19 coding for lamin B2 is developed for the identification of the origin of biional DNA synthesis in single-copy replicons of mammalian cells.

    Sequence Similarities: Belongs to the intermediate filament family.

    分子量
    70 kDa
    UniProt
    Q03252
    途径
    Apoptosis, Caspase Cascade in Apoptosis
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