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- 抗原 See all CISH 抗体
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
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抗原表位
- AA 241-258, C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CISH antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- 原理
- Anti-CISH Antibody Picoband®
- 序列
- LPLPRRMADY LRQYPFQL
- 交叉反应 （详细）
- No cross-reactivity with other proteins
- 产品特性
- Anti-CISH Antibody (ABIN3044172). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CISH, identical to the related rat and mouse sequences.
- 亚型
- IgG
- Top Product
- Discover our top product CISH Primary Antibody
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anti-Cytokine Inducible SH2-Containing Protein (CISH) (C-Term) antibody
CISH 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 79-256) antibodyCISH 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-257) antibodyCISH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 17-130) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 241-258) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) antibodyCISH 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-257) antibodyCISH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunocytochemistry , 0.5-1 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Hu, G., Zhou, R., Liu, J., Gong, A.-Y., Eischeid, A. N., Dittman, J. W., Chen, X.-M. MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge. J. Immun. 183: 1617-1624, 2009. 2. Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D., Rautanen, A., Mills, T. C., Chang, K.-C., Kam, K.-M., Crampin, A. C., and 23 others. CISH and susceptibility to infectious diseases. New Eng. J. Med. 362: 2092-2101, 2010. 3. Uchida, K., Yoshimura, A., Inazawa, J., Yanagisawa, K., Osada, H., Masuda, A., Saito, T., Takahashi, T., Miyajima, A., Takahashi, T. Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. Cytogenet. Cell Genet. 78: 209-212, 1997. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. - 有效期
- 12 months
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- 抗原
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- 别名
- CISH (CISH 产品)
- 背景
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Synonyms: Cytokine-inducible SH2-containing protein,CIS,CIS-1,Protein G18,Suppressor of cytokine signaling,SOCS,CISH,G18,
Tissue Specificity: Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. .
Background: CISH (cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
Sequence Similarities: Contains 1 SH2 domain.
- 分子量
- 29 kDa
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
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