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Kallikrein 6 抗体 (C-Term)

KLK6 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044157
发货至: 中国
  • 抗原 See all Kallikrein 6 (KLK6) 抗体
    Kallikrein 6 (KLK6)
    抗原表位
    • 15
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 227-244, C-Term
    适用
    • 38
    • 18
    • 10
    • 2
    • 1
    • 1
    宿主
    • 56
    • 5
    • 2
    克隆类型
    • 58
    • 5
    多克隆
    标记
    • 27
    • 10
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Kallikrein 6 antibody is un-conjugated
    应用范围
    • 48
    • 22
    • 21
    • 13
    • 13
    • 8
    • 7
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    原理
    Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.
    序列
    YTNVCRYTNW IQKTIQAK
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.
    Gene Name: kallikrein-related peptidase 6
    Protein Name: Kallikrein-6
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6(227-244aa YTNVCRYTNWIQKTIQAK).
    亚型
    IgG
    Top Product
    Discover our top product KLK6 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    有效期
    12 months
  • 抗原
    Kallikrein 6 (KLK6)
    别名
    KLK6 (KLK6 产品)
    别名
    Bssp antibody, Klk7 antibody, PRSS18 antibody, PRSS9 antibody, SP59 antibody, hK6 antibody, Prss9 antibody, AI849898 antibody, BSP antibody, Klk29 antibody, MSP antibody, Prss18 antibody, neurosin antibody, kallikrein related peptidase 6 antibody, kallikrein related-peptidase 6 antibody, kallikrein-6 antibody, KLK6 antibody, Klk6 antibody, LOC100716801 antibody
    背景
    KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

    Synonyms: Bssp antibody|hK 6 antibody|hK6 antibody|Kallikrein 6 precursor antibody|Kallikrein related peptidase 6 antibody|Kallikrein-6 antibody|Kallikrein6 antibody|KLK 6 antibody|Klk 7 antibody|KLK 9 antibody|Klk29 antibody|Klk6 antibody|KLK6_HUMAN antibody|Klk7 antibody|KLK9 antibody|MGC9355 antibody|mGK 1 antibody|mGK1 antibody|MSP antibody|Neurosin antibody|Protease M antibody|Protease serine 18 antibody|Protease serine 9 antibody|PRSS 18 antibody|PRSS 9 antibody|PRSS18 antibody|PRSS9 antibody|Serine protease 18 antibody|Serine protease 9 antibody|SP 59 antibody|SP59 antibody|Tissue kallikrein antibody|TK antibody|Zyme antibody
    UniProt
    Q92876
    途径
    Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
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