Kallikrein 6 抗体 (C-Term)
Quick Overview for Kallikrein 6 抗体 (C-Term) (ABIN3044157)
抗原
See all Kallikrein 6 (KLK6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 227-244, C-Term
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原理
- Anti-Kallikrein 6/KLK6 Antibody Picoband®
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序列
- YTNVCRYTNW IQKTIQAK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Kallikrein 6/KLK6 Antibody (ABIN3044157). Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6.
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亚型
- IgG
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anti-Kallikrein 6 (KLK6) (AA 17-244) antibody
KLK6 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (AA 22-244) antibodyKLK6 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (AA 91-190) antibodyKLK6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-Kallikrein 6 (KLK6) (AA 217-244) antibodyKLK6 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (AA 1-30), (N-Term) antibodyKLK6 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB6114 unconjugated
anti-Kallikrein 6 (KLK6) (AA 74-123) antibodyKLK6 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (Internal Region) antibodyVerified KLK6 适用: 人 IHC, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (C-Term) antibodyKLK6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein 6 (KLK6) (AA 126-156) antibodyKLK6 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB6116 unconjugated
anti-Kallikrein 6 (KLK6) (N-Term) antibodyKLK6 适用: 人, 犬, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunocytochemistry , 0.5-1 μg/mL, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Anisowicz, A., Sotiropoulou, G., Stenman, G., Mok, S. C., Sager, R. A novel protease homolog differentially expressed in breast and ovarian cancer. Molec. Med. 2: 624-636, 1996. 2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 3. Iwata, A., Maruyama, M., Akagi, T., Hashikawa, T., Kanazawa, I., Tsuji, S., Nukina, N. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Kallikrein 6 (KLK6)
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别名
- KLK6
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背景
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Synonyms: Kallikrein-6,3.4.21.-,Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme,KLK6,PRSS18, PRSS9,
Tissue Specificity: In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. .
Background: KLK6 (Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.
Sequence Similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.
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分子量
- 27 kDa
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UniProt
- Q92876
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途径
- Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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