HYAL1 抗体 (N-Term)
Quick Overview for HYAL1 抗体 (N-Term) (ABIN3043999)
抗原
See all HYAL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 32-47, N-Term
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原理
- Anti-Hyaluronidase-1 HYAL1 Antibody Picoband®
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序列
- FTTVWNANTQ WCLERH
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Hyaluronidase-1 HYAL1 Antibody (ABIN3043999). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human HYAL1.
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亚型
- IgG
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anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody
HYAL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibodyHYAL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) antibodyHYAL1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (Internal Region) antibodyVerified HYAL1 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 136-435) antibodyHYAL1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 1-253) antibodyHYAL1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 271-400) antibodyHYAL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 136-435) antibodyHYAL1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 60-159) antibodyHYAL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Hyaluronidase-1 (HYAL1) (AA 36-85) antibodyHYAL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunocytochemistry , 0.5-1 μg/mL, Human, -
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Monkey, Mouse, Rat
1. Csoka, A. B., Frost, G. I., Heng, H. H. Q., Scherer, S. W., Mohapatra, G., Stern, R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics 48: 63-70, 1998. Note: Erratum: Genomics 84: 227 only, 2004. 2. Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., Hombach-Klonisch, S., Csoka, A. B., Stern, R., Triggs-Raine, B. L. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum. Molec. Genet. 17: 1904-1915, 2008. Note: Erratum: Hum. Molec. Genet. 17: 2919 only, 2008. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- HYAL1 (Hyaluronidase-1 (HYAL1))
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别名
- HYAL1
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背景
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Synonyms: Hyaluronidase-1,Hyal-1,3.2.1.35,Hyaluronoglucosaminidase-1,Lung carcinoma protein 1,LuCa-1,HYAL1,LUCA1,
Tissue Specificity: Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. .
Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
Sequence Similarities: Belongs to the glycosyl hydrolase 56 family.
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分子量
- 60 kDa
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UniProt
- Q12794
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途径
- Glycosaminoglycan Metabolic Process
抗原
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