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Gelsolin 抗体 (C-Term)

Name: Gelsolin 抗体 (C-Term)
SKU: ABIN3043978
Availability: OutOfStock

This anti-Gelsolin antibody is a 兔多克隆 antibody detecting Gelsolin in WB, IHC, ICC, FACS 和 IF. Suitable for 人, 大鼠, 小鼠和猴. This Primary Antibody has been cited in 1 publication.

Western Blotting (WB) image for anti-Gelsolin (GSN) (AA 763-775), (C-Term) antibody (ABIN3043978) (Gelsolin 抗体 (C-Term))

Anti-Gelsolin antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue (Gelsolin 抗体 (C-Term))

IHC

Anti-Gelsolin antibody, IHC(P) IHC(P): Human Lung Cancer Tissue (Gelsolin 抗体 (C-Term))

IHC

Anti-Gelsolin antibody, IHC(P) IHC(P): Rat Cardiac Muscle Tissue (Gelsolin 抗体 (C-Term))

IHC

Anti-Gelsolin antibody, ICC ICC: NIH3T3 Cell (Gelsolin 抗体 (C-Term))

IHC

5 images

(1 reference)

产品编号 ABIN3043978

发货至: 中国

Quick Overview for Gelsolin 抗体 (C-Term) (ABIN3043978)

抗原

See all Gelsolin (GSN) 抗体

Gelsolin (GSN)

适用

人, 大鼠, 小鼠, 猴

宿主

兔

克隆类型

多克隆

标记

This Gelsolin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Discover our top product GSN Primary Antibody

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AA 763-775, C-Term

原理

Anti-Gelsolin/GSN Antibody Picoband®

序列

WDDDYWSVDP LDR

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Gelsolin/GSN Antibody (ABIN3043978). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Gelsolin, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

亚型

IgG
anti-Gelsolin (GSN) (AA 170-423) antibody
GSN 适用: Cow WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Gelsolin (GSN) (AA 577-771) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 674-782) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 673-782) antibody
GSN 适用: 人 WB, IP, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G5 unconjugated

anti-Gelsolin (GSN) (AA 543-782) antibody
GSN 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) antibody
GSN 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5E3B9 unconjugated

anti-Gelsolin (GSN) (AA 432-553) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Gelsolin (GSN) (AA 432-625) antibody
GSN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 1-782) antibody
GSN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (C-Term) antibody
KO Validated GSN 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Monkey, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry , 0.5-1 μg/mL, Mouse
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Kamada, S., Kusano, H., Fujita, H., Ohtsu, M., Koya, R. C., Kuzumaki, N., Tsujimoto, Y. A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin. Proc. Nat. Acad. Sci. 95: 8532-8537, 1998. 2. Kim, J., Lee, J. E., Heynen-Genel, S., Suyama, E., Ono, K., Lee, K., Ideker, T., Aza-Blanc, P., Gleeson, J. G. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 464: 1048-1051, 2010. 3. Vasconcellos, C. A., Allen, P. G., Wohl, M. E., Drazen, J. M., Janmey, P. A., Stossel, T. P. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science 263: 969-971, 1994.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Guo, Cui, Jiang, Zhang, Jiang: "Proteomics of acute heart failure in a rat post-myocardial infarction model." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1946-1956, (2018) (PubMed).
抗原

Gelsolin (GSN)

别名

GSN

背景

Synonyms: Gelsolin,AGEL,Actin-depolymerizing factor,ADF,Brevin,GSN,
Tissue Specificity: Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Background: Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor, it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.
Sequence Similarities: Belongs to the villin/gelsolin family.

分子量

90 kDa

UniProt

P06396

途径

Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy