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IGFBP3 抗体 (C-Term)

There are 2+ publications for this product available. The 兔 多克隆 anti-IGFBP3 antibody is suitable to detect IGFBP3 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC 和 ELISA.
产品编号 ABIN3043859
发货至: 中国
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Quick Overview for IGFBP3 抗体 (C-Term) (ABIN3043859)

抗原

See all IGFBP3 抗体
IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This IGFBP3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
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    C-Term

    原理

    Anti-IGFBP3 Antibody

    序列

    RREMEDTLNH LKFLNVLSPR GVHIPNCDKK GFYKKKQCR

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    预测反应

    identical to the related mouse,rat sequences.

    产品特性

    Anti-IGFBP3 Antibody. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human IGFBP-3, identical to the related mouse and rat sequences.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • Pu, Wen, Liu, Zheng, Xiao, Xu, Wang, Li, Zhang: "shRNA constructs targeting IGFBP-3 alleviate age related erectile dysfunction in the rat." in: The Journal of urology, Vol. 192, Issue 3, pp. 990-6, (2014) (PubMed).

    Pu, Zheng, Zhang, Xiao, Xu, Liu, Wang, Wen, Zhou, Wu: "Higher expression of mRNA and protein of insulin-like growth factor binding protein-3 in old rat penile tissues: implications for erectile dysfunction." in: The journal of sexual medicine, Vol. 8, Issue 8, pp. 2181-90, (2011) (PubMed).

  • 抗原

    IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

    别名

    IGFBP3

    背景

    Background: IGFBP3, Insulin-like growth fator-binding protein 3, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP3 is located on chromosome 7. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

    Gene Full Name: insulin like growth factor binding protein 3

    分子量

    40 kDa

    基因ID

    3486

    UniProt

    P17936

    途径

    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
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