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BDNF 抗体 (AA 129-247)

Name: BDNF 抗体 (AA 129-247)
SKU: ABIN3043798
Availability: OutOfStock

BDNF 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti-BDNF Picoband antibody, All lanes: Anti-BDNF at 0. (BDNF 抗体 (AA 129-247))

Anti-BDNF Picoband antibody, IHC(P): Mouse Brain Tissue (BDNF 抗体 (AA 129-247))

IHC

Anti-BDNF Picoband antibody, IHC(P): Rat Brain Tissue (BDNF 抗体 (AA 129-247))

IHC

IHC analysis of BDNF using anti-BDNF antibody . (BDNF 抗体 (AA 129-247))

IHC

4 images

(10 references)

产品编号 ABIN3043798

发货至: 中国

Datasheet as PDF

抗原 See all BDNF 抗体

BDNF (Brain-Derived Neurotrophic Factor (BDNF))
抗原表位
15

13

11

9

6

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 129-247
适用
106

53

50

9

8

6

4

4

3

3

3

1

1

1
人, 大鼠, 小鼠
宿主
99

20

3

3

2

2
兔
Compatible Secondaries
克隆类型
100

29
多克隆
标记
69

10

10

5

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This BDNF antibody is un-conjugated
应用范围
94

43

38

26

21

18

18

12

12

6

4

3

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-BDNF Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-BDNF Antibody Picoband® (ABIN3043798). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human BDNF recombinant protein (Position: H129-R247). Human BDNF shares 100% amino acid (aa) sequence identity with both mouse and rat BDNF.

亚型

IgG

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anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 151-247) antibody
BDNF 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 20-252) antibody
BDNF 适用: Pig WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 1-247) antibody
BDNF 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 1B10 unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (Internal Region) antibody
Verified BDNF 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 206-236) antibody
BDNF 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 129-247) antibody
BDNF 适用: 人, 大鼠, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) (AA 206-236), (C-Term) antibody
BDNF 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB14839 unconjugated

anti-Brain-Derived Neurotrophic Factor (BDNF) antibody
BDNF 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat1. Jones, K. R., Reichardt, L. F. : Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Nat. Acad. Sci. 87: 8060-8064, 1990. 2. Lee, R., Kermani, P., Teng, K. K., Hempstead, B. L. : Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948, 2001 . 3. Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., Timmusk, T. : Dissecting the human BDNF locus: biional transcription, complex splicing, and multiple promoters. Genomics 90: 397-406, 2007.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Yin, Liang, Wang, Yan, Yin, Wu, Su: "Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation." in: International journal of molecular medicine, Vol. 41, Issue 2, pp. 649-658, (2018) (PubMed).

Li, Wu, Miao, Xiong et al.: "Effects of Polysaccharide of Gastrodia Elata Blume and Electro-Acupuncture on Expressions of Brain-Derived Neurotrophic Factor and Stem Cell Factor Protein in Caudate Putamen of Focal Cerebral ..." in: Medical science monitor basic research, Vol. 22, pp. 175-180, (2017) (PubMed).

Zheng, Lu, Guo, Zhang, Liu, Guo, Huang, Han: "Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKA/CREB Signaling Pathway in Cerebral Hypoperfusion." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 7893710, (2016) (PubMed).

Tong, Wang, Li, Zhu, Chen, Hua: "Effects of senescence on the expression of BDNF and TrkB receptor in the lateral geniculate nucleus of cats." in: Dong wu xue yan jiu = Zoological research, Vol. 36, Issue 1, pp. 48-53, (2015) (PubMed).

Zhao, Chen, Shen, Zhao, Wang, Shi, Wang, Cui, Yan, Xue: "Transplantation of human umbilical cord blood mesenchymal stem cells to treat a rat model of traumatic brain injury." in: Neural regeneration research, Vol. 7, Issue 10, pp. 741-8, (2015) (PubMed).

Tan, Shi, Shi, Liu, Liu, Wang, Chen, Xing, Shen, Jia, Ye, He, Li: "Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles." in: Neural regeneration research, Vol. 8, Issue 3, pp. 233-43, (2014) (PubMed).

Li, Li, Li, Quan, Wang: "Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease." in: Neural regeneration research, Vol. 7, Issue 36, pp. 2860-6, (2014) (PubMed).

Wang, Feng, Fu, Li: "Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression." in: Experimental and therapeutic medicine, Vol. 6, Issue 3, pp. 826-830, (2013) (PubMed).

Li, Xia, Zhang, Wu: "S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk." in: PLoS ONE, Vol. 6, Issue 6, pp. e21663, (2011) (PubMed).

Shi, Shao, Yuan, Pan, Li: "Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus." in: Yonsei medical journal, Vol. 51, Issue 5, pp. 661-71, (2010) (PubMed).
抗原

BDNF (Brain-Derived Neurotrophic Factor (BDNF))

别名

BDNF (BDNF 产品)

背景

Synonyms: Brain-derived neurotrophic factor,BDNF,Bdnf,
Background: Brain-derived neurotrophic factor, also known as BDNF, is a secreted protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor. It is mapped to 11p14.1. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is expressed within peripheral ganglia and is not restricted to neuronal target fields. BDNF has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.

分子量

14 kDa

基因ID

12064

UniProt

P21237

途径

RTK signaling, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity