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- 抗原 See all Ataxin 3 (ATXN3) 抗体
- Ataxin 3 (ATXN3)
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抗原表位
- AA 226-254, C-Term
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Ataxin 3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P in Human,Rat.
- 序列
- EEDLQRALAL SRQEIDMEDE EADLRRAIQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: ataxin 3
Protein Name: Ataxin-3 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Ataxin 3 (226-254aa EEDLQRALALSRQEIDMEDEEADLRRAIQ), different from the related mouse and rat sequences by two amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ATXN3 Primary Antibody
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anti-Ataxin 3 (ATXN3) (AA 1-364) antibody
ATXN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 1-288) antibodyATXN3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyKO Validated ATXN3 适用: 人 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 261-288) antibodyATXN3 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23951 unconjugated
anti-Ataxin 3 (ATXN3) (AA 267-297), (Middle Region) antibodyATXN3 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 29-59) antibodyATXN3 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (N-Term) antibodyATXN3 适用: 人, 小鼠, 大鼠, Cow, 绵羊, 马, 兔, 豚鼠, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- 抗原
- Ataxin 3 (ATXN3)
- 别名
- ATXN3 (ATXN3 产品)
- 别名
- Mjd antibody, zgc:56323 antibody, ATXN3 antibody, at3 antibody, jos antibody, mjd antibody, atx3 antibody, mjd1 antibody, sca3 antibody, ataxin-3 antibody, MJD1 antibody, MGC83584 antibody, AT3 antibody, ATX3 antibody, JOS antibody, MJD antibody, SCA3 antibody, 2210008M02Rik antibody, AI463012 antibody, AI647473 antibody, Sca3 antibody, Rsca3 antibody, ataxin 3 antibody, ataxin 3 L homeolog antibody, ataxin-3 antibody, atxn3 antibody, ATXN3 antibody, atxn3.L antibody, MICPUN_104046 antibody, MICPUCDRAFT_46658 antibody, Atxn3 antibody
- 背景
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ATXN3 (Ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 ranges in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation. Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.
Synonyms: AT3 antibody|Ataxin 3 antibody|Ataxin-3 antibody|ATX3 antibody|ATX3_HUMAN antibody|ATXN3 antibody|EC 3.4.22. antibody|JOS antibody|Josephin antibody|Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) antibody|Machado Joseph disease antibody|Machado Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 homolog antibody|MJD antibody|MJD gene antibody|MJD1 antibody|Olivopontocerebellar ataxia 3 antibody| OTTHUMP00000221583 antibody|OTTHUMP00000221585 antibody|OTTHUMP00000221586 antibody| OTTHUMP00000221587 antibody|OTTHUMP00000231995 antibody|OTTHUMP00000231997 antibody|Rsca3 antibody|SCA3 antibody|SCA3 gene antibody|Spinocerebellar ataxia type 3 protein antibody - 基因ID
- 4287
- UniProt
- P54252
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