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Angiotensin I Converting Enzyme 1 抗体 (AA 651-864)

This anti-Angiotensin I Converting Enzyme 1 antibody is a 兔 多克隆 antibody detecting Angiotensin I Converting Enzyme 1 in WB, IHC, ICC, IHC (fro) 和 IF. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN3043777
发货至: 中国

Quick Overview for Angiotensin I Converting Enzyme 1 抗体 (AA 651-864) (ABIN3043777)

抗原

See all Angiotensin I Converting Enzyme 1 (ACE) 抗体
Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
  • 抗原表位

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    AA 651-864

    原理

    Anti-Angiotensin Converting Enzyme 1/ACE Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Angiotensin Converting Enzyme 1/ACE Antibody Picoband® (ABIN3043777). Tested in IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human ACE recombinant protein (Position: K651-Y864). Human ACE shares 73% and 76% amino acid (aa) sequences identity with mouse and rat ACE, respectively.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human1. Kierszenbaum, Abraham L. (2007). Histology and cell biology: an introduction to pathology. Mosby Elsevier 2. Jeunemaitre, X., Lifton, R. P., Hunt, S. C., Williams, R. R., Lalouel, J.-M. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nature Genet. 1: 72-75, 1992. 3. Mattei, M.-G., Hubert, C., Alhenc-Gelas, F., Roeckel, N., Corvol, P., Soubrier, F. Angiotensin-I converting enzyme gene is on chromosome 17. (Abstract) Cytogenet. Cell Genet. 51: 1041, 1989.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yan, Shen: "Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 3965-3973, (2018) (PubMed).

  • 抗原

    Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

    别名

    ACE

    背景

    Synonyms: Angiotensin-converting enzyme,ACE,3.2.1.-,3.4.15.1,Dipeptidyl carboxypeptidase I,Kininase II,CD143,Angiotensin-converting enzyme, soluble form,ACE,DCP, DCP1,

    Tissue Specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. .

    Background: Angiotensin-converting enzyme (ACE), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, ACE was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.

    Sequence Similarities: Belongs to the peptidase M2 family.

    分子量

    180 kDa

    基因ID

    1636

    UniProt

    P12821

    途径

    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
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