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Angiopoietin 2 抗体 (C-Term)

There are 3+ publications for this product available. The 兔 多克隆 anti-Angiopoietin 2 antibody is suitable to detect Angiopoietin 2 in samples from 人. It has been validated for WB.
产品编号 ABIN3043679
发货至: 中国
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Quick Overview for Angiopoietin 2 抗体 (C-Term) (ABIN3043679)

抗原

See all Angiopoietin 2 (ANGPT2) 抗体
Angiopoietin 2 (ANGPT2)

适用

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宿主

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克隆类型

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多克隆

标记

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This Angiopoietin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 454-468, C-Term

    原理

    Anti-Angiopoietin 2/ANGPT2 Antibody

    序列

    NLNGMYYPQR QNTNK

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Angiopoietin 2/ANGPT2 Antibody (ABIN3043679). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human Angiopoietin 2.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Huang, Pan, Yu, Guo, Wang, Zhang, Wang, Gao: "Benefical therapeutic effect of Chinese Herbal Xinji'erkang formula on hypertension-induced renal injury in the 2-kidney-1-clip hypertensive rats." in: African journal of traditional, complementary, and alternative medicines : AJTCAM, Vol. 11, Issue 5, pp. 16-27, (2015) (PubMed).

    Bai, Li, Tian, Zhou: "Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes." in: PLoS ONE, Vol. 9, Issue 4, pp. e96117, (2014) (PubMed).

    Li, Fan, Song, Zhang, Chen, Li, Mi, Ma, Song, Tao, Li: "Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma." in: PLoS ONE, Vol. 8, Issue 9, pp. e75388, (2013) (PubMed).

  • 抗原

    Angiopoietin 2 (ANGPT2)

    别名

    ANGPT2

    背景

    Synonyms: Angiopoietin-2,ANG-2,ANGPT2,

    Tissue Specificity: Widely expressed, with highest expression in brain. .

    Background: Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60 % homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

    Sequence Similarities: Contains 1 fibrinogen C-terminal domain.

    分子量

    57 kDa

    UniProt

    O15123

    途径

    RTK signaling
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