NFKBIB 抗体 (AA 56-237)
Quick Overview for NFKBIB 抗体 (AA 56-237) (ABIN3043567)
抗原
See all NFKBIB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 56-237
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原理
- Anti-IKB beta/NFKBIB Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-IKB beta/NFKBIB Antibody Picoband® (ABIN3043567). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human IKB beta recombinant protein (Position: E56-E237). Human IKB beta shares 82% and 80% amino acid (aa) sequence identity with mouse and rat IKB beta, respectively.
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亚型
- IgG
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anti-NF-kappa-B inhibitor beta (NFKBIB) (AA 85-332) antibody
NFKBIB 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (pSer23) antibodyNFKBIB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) antibodyNFKBIB 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (AA 1-356) antibodyNFKBIB 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G6 unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (AA 1-356) antibodyNFKBIB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) antibodyNFKBIB 适用: 人, 小鼠, 大鼠 IHC (p), IF 宿主: 小鼠 Monoclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (AA 56-145) antibodyNFKBIB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (C-Term) antibodyNFKBIB 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) (N-Term) antibodyNFKBIB 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-NF-kappa-B inhibitor beta (NFKBIB) antibodyNFKBIB 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Okamoto T, Ono T, Hori M, Yang J, Tetsuka T, Kawabe T et al. (November 1998). "Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization". Cytogenet Cell Genet 82 (1-2): 105-6. 2. Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., Oeckinghaus, A., Lynch, C., Hoffmann, A., Baltimore, D., Ghosh, S. I-kappa-B-beta acts to inhibit and activate gene expression during the inflammatory response. Nature 466: 1115-1119, 2010. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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别名
- NFKBIB
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背景
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Synonyms: NF-kappa-B inhibitor beta,NF-kappa-BIB,I-kappa-B-beta,IkB-B,IkB-beta,IkappaBbeta,Thyroid receptor-interacting protein 9,TR-interacting protein 9,TRIP-9,NFKBIB,IKBB, TRIP9,
Tissue Specificity: Expressed in all tissues examined.
Background: NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. This gene is mapped to 19q13.2. It has been found that in vivo, NFKBIB serves both to inhibit and to facilitate the inflammatory response. NFKBIB degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as TNF-alpha. Surprisingly, absence of NFKBIB results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.
Sequence Similarities: Belongs to the NF-kappa-B inhibitor family.
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分子量
- 38 kDa
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基因ID
- 4793
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UniProt
- Q15653
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途径
- NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
抗原
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