TICAM1 抗体 (N-Term)
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北京 101111
Quick Overview for TICAM1 抗体 (N-Term) (ABIN3043539)
抗原
See all TICAM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-TRIF/TICAM1 Antibody
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序列
- QDTEARVSLE SLKMNTVAQL VAHQWADMET TE
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- different from the related human sequence by twelve amino acids.
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产品特性
- Anti-TRIF/TICAM1 Antibody. Tested in WB applications. This antibody reacts with Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of mouse TRIF, different from the related human sequence by twelve amino acids.
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亚型
- IgG
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anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 443-685) antibody
TICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 263-526) antibodyTICAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibodyTICAM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyTICAM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyVerified TICAM1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 120-420) antibodyTICAM1 适用: 人, 猴 WB 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 115-143), (N-Term) antibodyTICAM1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyVerified TICAM1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Western blot, 0.1-0.5 μg/mL, Mouse, Rat
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling ..." in: Cell stress & chaperones, Vol. 21, Issue 4, pp. 697-705, (2017) (PubMed).
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- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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别名
- Ticam1
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背景
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Background: TICAM1 (TIR DOMAIN-CONTAINING ADAPTOR MOLECULE 1), also known as TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al. (2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al. (2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2. Small interfering (si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
Gene Full Name: TIR domain containing adaptor molecule 1
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分子量
- 110 kDa
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基因ID
- 106759
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UniProt
- Q80UF7
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
抗原
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