Src 抗体 (AA 2-368)
(1 reference)Quick Overview for Src 抗体 (AA 2-368) (ABIN3043441)
抗原
See all Src 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-368
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原理
- Anti-Src Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Src Antibody (ABIN3043441). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Src recombinant protein (Position: G2-D368). Human Src shares 97% and 99% amino acid (aa) sequences identity with mouse and rat Src, respectively.
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亚型
- IgG
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anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
Src 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr530) antibodySrc 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibodySrc 适用: 人, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 17AT28 unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 24-52), (N-Term) antibodySrc 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB41141 unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibodyKO Validated Src 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 397-424) antibodySrc 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 24-52) antibodySrc 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr529) antibodySrc 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr419) antibodySrc 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 1-90) antibodySrc 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 1B9 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/?-catenin pathway." in: Oncotarget, Vol. 6, Issue 5, pp. 3123-35, (2015) (PubMed).
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: "Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/?-catenin pathway." in: Oncotarget, Vol. 6, Issue 5, pp. 3123-35, (2015) (PubMed).
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- Src (Proto-oncogene tyrosine-protein kinase Src (Src))
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别名
- SRC
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背景
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Synonyms: Proto-oncogene tyrosine-protein kinase Src,2.7.10.2,Proto-oncogene c-Src,pp60c-src,p60-Src,SRC,SRC1,
Tissue Specificity: Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Background: Sarcoma (Scr) is a proto-oncogenic tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus. belongs to a family of non-receptor tyrosine kinases called Src family kinases. The human SRC protooncogene was assigned to chromosome 20. Its gene is mapped to 20q12-q13. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry. This proto-oncogene may play a role in the regulation of embryonic development and cell growth.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
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分子量
- 60 kDa
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基因ID
- 6714
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UniProt
- P12931
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途径
- JAK/STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
抗原
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