Growth Hormone Receptor 抗体 (Middle Region)
Quick Overview for Growth Hormone Receptor 抗体 (Middle Region) (ABIN3043066)
抗原
See all Growth Hormone Receptor (GHR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 231-247, Middle Region
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原理
- Anti-Growth hormone receptor/GHR Antibody Picoband®
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序列
- DKEHEVRVRS RQRSFEK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Growth hormone receptor/GHR Antibody (ABIN3043066). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor, identical to the related rat sequence.
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亚型
- IgG
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anti-Growth Hormone Receptor (GHR) (AA 101-200) antibody
GHR 适用: 人, 小鼠, 大鼠, Pig, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (AA 353-588) antibodyGHR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) antibodyGHR 适用: 人 ELISA, IHC, IF 宿主: 兔 Monoclonal 10C11 unconjugated Recombinant Antibody
anti-Growth Hormone Receptor (GHR) (AA 19-118) antibodyGHR 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3A12 unconjugated
anti-Growth Hormone Receptor (GHR) (AA 315-574) antibodyGHR 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (AA 36-266) antibodyGHR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (N-Term) antibodyGHR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (AA 19-184) antibodyGHR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (AA 19-118) antibodyGHR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Hormone Receptor (GHR) (AA 36-85) antibodyGHR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Rat
1. Barton, D. E., Foellmer, B. E., Wood, W. I., Francke, U. : Chromosome mapping of the growth hormone receptor gene in man and mouse. Cytogenet. Cell Genet. 50: 137-141, 1989. 2. Godowski, P. J., Leung, D. W., Meacham, L. R., Galgani, J. P., Hellmiss, R., Keret, R., Rotwein, P. S., Parks, J. S., Laron, Z., Wood, W. I. : Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. Proc. Nat. Acad. Sci. 86: 8083-8087, 1989. 3. Amselem, S., Sobrier, M.-L., Duquesnoy, P., Rappaport, R., Postel-Vinay, M.-C., Gourmelen, M., Dallapiccola, B., Goossens, M. : Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism. J. Clin. Invest. 87: 1098-1102, 1991. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Growth Hormone Receptor (GHR)
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别名
- GHR
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背景
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Synonyms: Growth hormone receptor,GH receptor,Somatotropin receptor,Growth hormone-binding protein,GH-binding protein,GHBP,Serum-binding protein,Ghr,
Tissue Specificity: Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.
Background: The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3 (d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome (GHIS).
Sequence Similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.
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分子量
- 72 kDa
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UniProt
- P16882
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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