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Notch1 抗体 (Middle Region)

Cited in 1 publication. This anti-Notch1 antibody is a 兔 多克隆 antibody detecting Notch1 in WB. Suitable for 人.
产品编号 ABIN3043031
发货至: 中国
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Quick Overview for Notch1 抗体 (Middle Region) (ABIN3043031)

抗原

See all Notch1 (NOTCH1) 抗体
Notch1 (NOTCH1) (Notch 1 (NOTCH1))

适用

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宿主

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克隆类型

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多克隆

标记

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This Notch1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
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    AA 2487-2506, Middle Region

    原理

    Anti-Notch1 Antibody

    序列

    QHSYSSPVDN TPSHQLQVPE

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Notch1 Antibody (ABIN3043031). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence in the middle region of human Notch1.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Mi, Chen, Zheng, Li, Zhang, Mo, Yang: "MicroRNA-139-5p Suppresses 3T3-L1 Preadipocyte Differentiation Through Notch and IRS1/PI3K/Akt Insulin Signaling Pathways." in: Journal of cellular biochemistry, Vol. 116, Issue 7, pp. 1195-204, (2015) (PubMed).

  • 抗原

    Notch1 (NOTCH1) (Notch 1 (NOTCH1))

    别名

    NOTCH1

    背景

    Synonyms: Neurogenic locus notch homolog protein 1,Notch 1,hN1,Translocation-associated notch protein TAN-1,Notch 1 extracellular truncation,NEXT,Notch 1 intracellular domain,NICD,NOTCH1,TAN1,

    Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

    Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

    Sequence Similarities: Belongs to the NOTCH family.

    分子量

    272 kDa

    UniProt

    P46531

    途径

    Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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