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IL-18 抗体 (AA 36-192)

IL18 适用: 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042801
发货至: 中国
  • 抗原 See all IL-18 (IL18) 抗体
    IL-18 (IL18) (Interleukin 18 (IL18))
    抗原表位
    • 37
    • 13
    • 11
    • 8
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    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
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    AA 36-192
    适用
    • 97
    • 35
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    • 15
    • 9
    • 7
    • 5
    • 3
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    • 2
    • 1
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    小鼠
    宿主
    • 122
    • 56
    • 4
    • 2
    • 1
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    克隆类型
    • 117
    • 65
    • 3
    多克隆
    标记
    • 111
    • 16
    • 13
    • 5
    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 1
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    This IL-18 antibody is un-conjugated
    应用范围
    • 121
    • 89
    • 78
    • 74
    • 40
    • 26
    • 17
    • 17
    • 8
    • 3
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    原理
    Anti-Interleukin-18 IL18 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    < a href="https://www.bosterbio.com/anti-il-18-antibody-pa1342-boster.html" style="color:#EA8D28">Anti-Interleukin-18 IL18 Antibody (ABIN3042801). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E. coli-derived mouse IL-18 recombinant protein (Position: N36-S192).
    亚型
    IgG
    Top Product
    Discover our top product IL18 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Mouse
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse
    ELISA, 0.1-0.5 μg/mL, -
    1. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature 378 (6552): 88-91. 2. Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics 51 (1): 161-3.. 3. "Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)". 4. Nolan, K. F., Greaves, D. R., Waldmann, H. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51: 161-163, 1998.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Si, Zhang, Gao, Chen, Zhao, Cheng: "Effects of IFN-? on IL-18 Expression in Pregnant Rats and Pregnancy Outcomes." in: Asian-Australasian journal of animal sciences, Vol. 26, Issue 10, pp. 1399-405, (2014) (PubMed).

    Wang, Zhang, Zhang, Xu, Fang: "Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats." in: Journal of reproductive immunology, Vol. 92, Issue 1-2, pp. 45-53, (2011) (PubMed).

    Yang, Shen, Chen, Ge: "Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion." in: World journal of gastroenterology, Vol. 11, Issue 29, pp. 4524-9, (2005) (PubMed).

  • 抗原
    IL-18 (IL18) (Interleukin 18 (IL18))
    别名
    IL18 (IL18 产品)
    背景

    Synonyms: Interleukin-18,IL-18,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma,Il18,Igif,

    Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

    Background: Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.

    Sequence Similarities: Belongs to the IL-10 family.

    分子量
    22 kDa
    UniProt
    P70380
    途径
    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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