CSNK1A1 抗体 (N-Term)
Quick Overview for CSNK1A1 抗体 (N-Term) (ABIN3042767)
抗原
See all CSNK1A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-68, N-Term
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原理
- Anti-Caseine Kinase 1 alpha/CSNK1A1 Antibody Picoband®
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序列
- DIYLAINITN GEEVAVKLES QKARHPQLLY ESKLYKILQ
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Caseine Kinase 1 alpha/CSNK1A1 Antibody Picoband® (ABIN3042767). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human CSNK1A1, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Casein Kinase 1, alpha 1 (CSNK1A1) (Internal Region) antibody
CSNK1A1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (AA 100-200) antibodyCSNK1A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (pTyr294) antibodyCSNK1A1 适用: 人, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (AA 2-337), (Isoform alpha) antibodyCSNK1A1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) antibodyCSNK1A1 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) antibodyCSNK1A1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) antibodyCSNK1A1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 3C10F7 unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (AA 130-337) antibodyCSNK1A1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (AA 114-324) antibodyCSNK1A1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 1, alpha 1 (CSNK1A1) (AA 309-337), (C-Term) antibodyCSNK1A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00886 unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Bidere, N., Ngo, V. N., Lee, J., Collins, C., Zheng, L., Wan, F., Davis, R. E., Lenz, G., Anderson, D. E., Arnoult, D., Vazquez, A., Sakai, K., Zhang, J., Meng, Z., Veenstra, T. D., Staudt, L. M., Lenardo, M. J. Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009. 2. Elyada, E., Pribluda, A., Goldstein, R. E., Morgenstern, Y., Brachya, G., Cojocaru, G., Snir-Alkalay, I., Burstain, I., Haffner-Krausz, R., Jung, S., Wiener, Z., Alitalo, K., Oren, M., Pikarsky, E., Ben-Neriah, Y. CKI-alpha ablation highlights a critical role for p53 in invasiveness control. Nature 470: 409-413, 2011. 3. Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters 349 (2): 307-12. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))
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别名
- CSNK1A1
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背景
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Synonyms: Casein kinase I isoform alpha,CKI-alpha,2.7.11.1,CK1,CSNK1A1,
Background: Casein kinase I isoform alpha?is an?enzyme?that in humans is encoded by the?CSNK1A1?gene. The?CSNK1A1?gene is mapped to chromosome 5q32 based on an alignment of the?CSNK1A1?sequence with the genomic sequence (GRCh37). It is reported that both screens identified CK1-alpha as a bifunctional regulator of NF-kappa-B. CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. However, CK1-alpha kinase activity has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. CK1-alpha has thus a dual 'gating' function which first promotes and then terminates receptor-induced NF-kappa-B. ABC DLBCL cells required CK1-alpha for constitutive NF-kappa-B activity, indicating that CK1-alpha functions as a conditionally essential malignancy gene.?
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分子量
- 39 kDa
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基因ID
- 1452
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UniProt
- P48729
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途径
- WNT signaling, Hedgehog Signaling
抗原
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