CREB1 抗体 (AA 1-177)
Quick Overview for CREB1 抗体 (AA 1-177) (ABIN3042756)
抗原
See all CREB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-177
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原理
- Anti-CREB/CREB1 Antibody Picoband®
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交叉反应 (详细)
- No cross-reactivity with other proteins
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产品特性
- Anti-CREB/CREB1 Antibody Picoband® (ABIN3042756). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CREB recombinant protein (Position: M1-T177). Human CREB shares 99% and 98% amino acid (aa) sequences identity with mouse and rat CREB, respectively.
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (December 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science 242 (4884): 1430-3. 2. Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (July 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics 7 (3): 416-21. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease." in: Journal of biomedical science, Vol. 20, pp. 87, (2014) (PubMed).
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LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease." in: Journal of biomedical science, Vol. 20, pp. 87, (2014) (PubMed).
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- CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
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别名
- CREB1
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背景
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Synonyms: Cyclic AMP-responsive element-binding protein 1,CREB-1,cAMP-responsive element-binding protein 1,CREB1,
Tissue Specificity: Highly expressed in placenta.
Background: CREB1, also known as cAMP responsive element binding protein 1, is a protein that in humans is encoded by the CREB1 gene. It is mapped to 2q33.3. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
Sequence Similarities: Belongs to the bZIP family.
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分子量
- 43 kDa
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基因ID
- 12912
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UniProt
- P16220
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途径
- TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
抗原
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