Nicastrin 抗体 (N-Term)
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Quick Overview for Nicastrin 抗体 (N-Term) (ABIN3042580)
抗原
See all Nicastrin (NCSTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 72-88, N-Term
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原理
- Anti-Nicastrin/NCSTN Antibody
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序列
- VIHVVEKEED LQWVLTD
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Nicastrin/NCSTN Antibody (ABIN3042580). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
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亚型
- IgG
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anti-Nicastrin (NCSTN) antibody
KD Validated NCSTN 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1040 unconjugated Recombinant Antibody
anti-Nicastrin (NCSTN) (AA 429-669) antibodyNCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 16-115) antibodyNCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 21-120) antibodyNCSTN 适用: 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 99-133) antibodyNCSTN 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB53031 unconjugated
anti-Nicastrin (NCSTN) (C-Term) antibodyNCSTN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 1-689) antibodyNCSTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 16-115) antibodyNCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Nicastrin (NCSTN) (AA 420-655) antibodyNCSTN 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 35-534) antibodyNCSTN 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Nicastrin (NCSTN)
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别名
- NCSTN
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背景
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Synonyms: Nicastrin,NCSTN,KIAA0253,UNQ1874/PRO4317,
Tissue Specificity: Widely expressed. .
Background: Nicastrin, also known as?NCSTN, is a?protein?that is a part of the gamma secretase?protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase?protein complex, all of which undergo significant post-translational modification?before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.?The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.?The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, an?enzyme?involved in the degradation of amyloid beta fragment.
Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
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分子量
- 120-130 kDa
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UniProt
- Q92542
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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