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Nicastrin 抗体 (N-Term)

Name: Nicastrin 抗体 (N-Term)
SKU: ABIN3042580
Availability: OutOfStock

NCSTN 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Observed bind size: 78KD (Nicastrin 抗体 (N-Term))

1 image

产品编号 ABIN3042580

发货至: 中国

Datasheet as PDF

抗原 See all Nicastrin (NCSTN) 抗体

Nicastrin (NCSTN)
抗原表位
15

3

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 72-88, N-Term
适用
36

32

20

5

5

4

1

1
人, 大鼠
宿主
50

2
兔
Compatible Secondaries
克隆类型
42

10
多克隆
标记
20

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Nicastrin antibody is un-conjugated
应用范围
38

13

13

9

7

4

4

3

3

2

2
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for Nicastrin(NCSTN) detection. Tested with WB in Human,Mouse,Rat.

序列

VIHVVEKEED LQWVLTD

交叉反应（详细）

Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

产品特性

Rabbit IgG polyclonal antibody for Nicastrin(NCSTN) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: nicastrin
Protein Name: Nicastrin

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin(72-88aa VIHVVEKEEDLQWVLTD), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

亚型

IgG

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anti-Nicastrin (NCSTN) (N-Term) antibody
NCSTN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
抗原

Nicastrin (NCSTN)

别名

NCSTN (NCSTN 产品)

背景

Nicastrin, also known as NCSTN, is a protein that is a part of the gamma secretase protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase protein complex, all of which undergo significant post-translational modification before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.

Synonyms: Anterior pharynx defective 2 antibody|APH 2 antibody|APH2 antibody|ATAG1874 antibody|KIAA0253 antibody|Ncstn antibody|NCT antibody|NICA_HUMAN antibody|Nicastrin antibody|RP11 517F10.1 antibody|RP11517F101 antibody

UniProt

Q92542

途径

Notch Signaling, Neurotrophin Signaling Pathway