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Nicastrin 抗体 (N-Term)

This anti-Nicastrin antibody is a 兔多克隆 antibody detecting Nicastrin in WB. Suitable for 人.

Observed bind size: 78KD (Nicastrin 抗体 (N-Term))

1 image

产品编号 ABIN3042580

发货至: 中国

Quick Overview for Nicastrin 抗体 (N-Term) (ABIN3042580)

抗原

See all Nicastrin (NCSTN) 抗体

Nicastrin (NCSTN)

适用

40
33
22
5
5
4
1
1

人

宿主

兔

克隆类型

多克隆

标记

25
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

This Nicastrin antibody is un-conjugated

应用范围

43
13
13
11
8
7
6
6
6
3
2

Western Blotting (WB)

Discover our top product NCSTN Primary Antibody

抗原表位
15

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 72-88, N-Term

原理

Anti-Nicastrin/NCSTN Antibody Picoband®

序列

VIHVVEKEED LQWVLTD

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Nicastrin/NCSTN Antibody (ABIN3042580). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

亚型

IgG
anti-Nicastrin (NCSTN) (AA 16-115) antibody
NCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 429-669) antibody
NCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 21-120) antibody
NCSTN 适用: 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 99-133) antibody
NCSTN 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB53031 unconjugated

anti-Nicastrin (NCSTN) (AA 1-689) antibody
NCSTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 16-115) antibody
NCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E8 unconjugated

anti-Nicastrin (NCSTN) (C-Term) antibody
NCSTN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 420-655) antibody
NCSTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (AA 35-534) antibody
NCSTN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nicastrin (NCSTN) (Center) antibody
NCSTN 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: NCSTN nicastrin" 2. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996)."Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321-9, 341-54. 3. Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H (April 2005)."Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components".J. Biol. Chem. 280 (17): 17020-6.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

Nicastrin (NCSTN)

别名

NCSTN

背景

Synonyms: Nicastrin,NCSTN,KIAA0253,UNQ1874/PRO4317,
Tissue Specificity: Widely expressed. .
Background: Nicastrin, also known as?NCSTN, is a?protein?that is a part of the gamma secretase?protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase?protein complex, all of which undergo significant post-translational modification?before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.?The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.?The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, an?enzyme?involved in the degradation of amyloid beta fragment.
Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

分子量

120-130 kDa

UniProt

Q92542

途径

Notch Signaling, Neurotrophin Signaling Pathway

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