Plakophilin 2 抗体 (C-Term)
Quick Overview for Plakophilin 2 抗体 (C-Term) (ABIN3042556)
抗原
See all Plakophilin 2 (PKP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 863-881, C-Term
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原理
- Anti-Plakophilin 2/PKP2 Antibody Picoband®
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序列
- KKTDFVNSRT AKAYHSLKD
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Plakophilin 2/PKP2 Antibody (ABIN3042556). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Plakophilin 2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-Plakophilin 2 (PKP2) (AA 801-881) antibody
PKP2 适用: 人 ELISA, IHC (p), ICC, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (N-Term) antibodyPKP2 适用: 人, 大鼠, 小鼠, 犬, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (C-Term) antibodyPKP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 61-183) antibodyPKP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 125-139) antibodyVerified PKP2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (C-Term) antibodyPKP2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 1-350) antibodyPKP2 适用: 人, 小鼠 WB, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 8H6 unconjugated
anti-Plakophilin 2 (PKP2) (N-Term) antibodyPKP2 适用: 人, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) (AA 571-849) antibodyPKP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plakophilin 2 (PKP2) antibodyPKP2 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1 "Entrez Gene: PKP2 plakophilin 2" 2 Marcus, F. I., Fontaine, G. H., Guiraudon, G., Frank, R., Laurenceau, J. L., Malergue, C., Grosgogeat, Y. Right ventricular dysplasia: a report of 24 adult cases. Circulation 65: 384-398, 1982. 3 Mertens C, Kuhn C, Franke WW (Jan 1997). "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque". J Cell Biol 135 (4): 1009-25. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Plakophilin 2 (PKP2)
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别名
- PKP2
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背景
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Synonyms: Plakophilin-2,PKP2,
Tissue Specificity: Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. .
Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. It is mapped to 12p11.21. PKP2 is a constituent of the desmosomal plaque in simple epithelia, some stratified epithelia, and some nonepithelial cells. PKP2 is also enriched in the karyoplasm of cells of various types, including those lacking desmosomes. Plakophilin proteins participate in linking cadherins to intermediate filaments in the cytoskeleton and this gene product may regulate the signaling activity of beta-catenin. PKP2 has been shown to interact with Desmoplakin, Plakoglobin and Desmoglein 1.
Sequence Similarities: Belongs to the beta-catenin family.
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分子量
- 97 kDa
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UniProt
- Q99959
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途径
- Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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