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Gelsolin 抗体 (AA 580-782)

Name: Gelsolin 抗体 (AA 580-782)
SKU: ABIN3042436
Availability: OutOfStock

GSN 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti- Gelsolin antibody, Western blotting All lanes: Anti Gelsolin at 0. (Gelsolin 抗体 (AA 580-782))

Anti- Gelsolin antibody, IHC(P) IHC(P): Mouse Spleen Tissue (Gelsolin 抗体 (AA 580-782))

IHC

Anti- Gelsolin antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (Gelsolin 抗体 (AA 580-782))

IHC

Anti- Gelsolin antibody, IHC(P) IHC(P): Rat Spleen Tissue (Gelsolin 抗体 (AA 580-782))

IHC

5 images

(1 reference)

产品编号 ABIN3042436

发货至: 中国

Datasheet as PDF

抗原 See all Gelsolin (GSN) 抗体

Gelsolin (GSN)
抗原表位
16

8

5

5

4

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 580-782
适用
89

30

23

10

6

3

2

2

2

2

1

1

1
人, 小鼠, 大鼠
宿主
74

24

2
兔
Compatible Secondaries
克隆类型
68

32
多克隆
标记
56

9

5

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1
This Gelsolin antibody is un-conjugated
应用范围
77

30

22

20

18

17

15

14

13

9

4

3

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Gelsolin(GSN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Gelsolin(GSN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: gelsolin
Protein Name: Gelsolin

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Gelsolin recombinant protein (Position: E580-A782). Human Gelsolin shares 94% and 95% amino acid (aa) sequences identity with mouse and rat Gelsolin, respectively.

亚型

IgG

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anti-Gelsolin (GSN) (AA 673-782) antibody
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anti-Gelsolin (GSN) (AA 543-782) antibody
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GSN 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5E3B9 unconjugated

anti-Gelsolin (GSN) (AA 432-553) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Gelsolin (GSN) (AA 432-625) antibody
GSN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 1-782) antibody
GSN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (C-Term) antibody
KO Validated GSN 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Gelsolin is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Guo, Cui, Jiang, Zhang, Jiang: "Proteomics of acute heart failure in a rat post-myocardial infarction model." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1946-1956, (2018) (PubMed).
抗原

Gelsolin (GSN)

别名

GSN (GSN 产品)

别名

ADF antibody, AGEL antibody, CG1106 antibody, DGS antibody, Dmel\\CG1106 antibody, gel antibody, scin antibody, cb107 antibody, gsn antibody, sb:cb107 antibody, u-gelsolin antibody, wu:fi16f06 antibody, gelsolin antibody, Gelsolin antibody, gelsolin S homeolog antibody, gelsolin a antibody, GSN antibody, Gel antibody, Gsn antibody, gsn.S antibody, gsn antibody, gsna antibody

背景

Gelsolin, also known as GNS or brevin, is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. It is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.

Synonyms: Actin depolymerizing factor antibody|Actin-depolymerizing factor antibody|ADF antibody|AGEL antibody|Brevin antibody|DKFZp313L0718 antibody|GELS_HUMAN antibody|Gelsolin antibody|GSN antibody

基因ID

2934

UniProt

P06396

途径

Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy