Estrogen Receptor alpha 抗体 (AA 425-595)
(5 references)-
- 抗原 See all Estrogen Receptor alpha (ESR1) 抗体
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
-
抗原表位
- AA 425-595
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This Estrogen Receptor alpha antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Estrogen receptor(ESR1) detection. Tested with WB, IHC-P in Human.
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
-
Rabbit IgG polyclonal antibody for Estrogen receptor(ESR1) detection. Tested with WB, IHC-P in Human.
Gene Name: estrogen receptor 1
Protein Name: Estrogen receptor - 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.
- 亚型
- IgG
- Top Product
- Discover our top product ESR1 Primary Antibody
-
anti-Estrogen Receptor 1 (ESR1) (AA 129-312) antibody
ESR1 适用: 人 IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal ESR1-3557 unconjugated
anti-Estrogen Receptor 1 (ESR1) antibodyESR1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal ESR1-1904 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 适用: 人, 大鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6A6E8 unconjugated
anti-Estrogen Receptor 1 (ESR1) (pSer167) antibodyESR1 适用: 人, 大鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 适用: 人 WB, IHC, FACS, StM 宿主: 小鼠 Monoclonal ER506 unconjugated
anti-Estrogen Receptor 1 (ESR1) (C-Term) antibodyESR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibodyESR1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33807 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibodyESR1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (pSer118) antibodyESR1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 331-360) antibodyESR1 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc) 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Estrogen Receptor is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
-
-
: "Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4." in: Oncotarget, Vol. 9, Issue 4, pp. 4475-4484, (2018) (PubMed).
: "Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer." in: International journal of molecular medicine, Vol. 42, Issue 1, pp. 105-114, (2018) (PubMed).
: "The ability of 17 β-estradiol to attenuate intrahepatic vasoconstriction to endothelin-1 in female rats is lost in cirrhosis." in: Annals of hepatology, Vol. 14, Issue 3, pp. 404-13, (2016) (PubMed).
: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).
: "Letrozole inhibits the osteogenesis of medullary bone in prelay pullets." in: Poultry science, Vol. 89, Issue 5, pp. 917-23, (2010) (PubMed).
-
: "Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4." in: Oncotarget, Vol. 9, Issue 4, pp. 4475-4484, (2018) (PubMed).
-
- 抗原
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
- 别名
- ESR1 (ESR1 产品)
- 别名
- LOC398734 antibody, AA420328 antibody, AU041214 antibody, ER-alpha antibody, ER[a] antibody, ERa antibody, ERalpha antibody, ESR antibody, Estr antibody, Estra antibody, Nr3a1 antibody, NR3A1 antibody, eralpha antibody, zfER[a] antibody, ER antibody, ESRA antibody, ESTRR antibody, Era antibody, akap12 antibody, cb27 antibody, esr1 antibody, fb72g12 antibody, id:ibd1202 antibody, sb:cb27 antibody, si:ch73-192g21.1 antibody, wu:fb72g12 antibody, wu:fc21c03 antibody, Esr antibody, RNESTROR antibody, ERALPHA antibody, er antibody, esr antibody, nr3a1 antibody, XER antibody, era antibody, esra antibody, ERbeta antibody, xesr-1 antibody, xlERalpha1 antibody, xlERalpha2 antibody, ESR1 antibody, estrogen receptor 1 L homeolog antibody, estrogen receptor 1 (alpha) antibody, estrogen receptor 1 antibody, A kinase (PRKA) anchor protein 12b antibody, esr1.L antibody, Esr1 antibody, ESR1 antibody, esr1 antibody, akap12b antibody
- 背景
-
Estrogen receptor alpha (ER-α), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-α is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.
Synonyms: Atherosclerosis, susceptibility to, included antibody|DKFZp686N23123 antibody|ER Alpha antibody|ER antibody|ER Beta antibody|ER-alpha antibody|ER[a] antibody|ER[b] antibody|ERA antibody|ERalpha antibody|Erb antibody|Erb2 antibody|ERbeta antibody|ESR 1 antibody|ESR antibody|ESR BETA antibody|ESR1 antibody|ESR1_HUMAN antibody|ESR2 antibody|ESRA antibody|ESRB antibody|Estr antibody|Estra antibody|Estradiol Receptor alpha antibody|Estradiol Receptor antibody|Estradiol Receptor beta antibody|ESTRB antibody|Estrogen receptor 1 (alpha) antibody|Estrogen receptor 1 antibody|Estrogen receptor 2 (ER beta) antibody|Estrogen Receptor 2 antibody|Estrogen receptor 2 ER beta antibody|Estrogen receptor alpha antibody|Estrogen receptor antibody|Estrogen receptor beta 4 antibody|Estrogen resistance, included antibody|HDL cholesterol, augmented response of, to hormone replacement, included antibody|Myocardial infarction, susceptibility to, included antibody|NR3A 1 antibody|NR3A1 antibody|NR3A2 antibody|Nuclear receptor subfamily 3 group A member 1 antibody|Nuclear receptor subfamily 3 group A member 2 antibody|OTTHUMP00000017718 antibody|OTTHUMP00000017719 antibody|RNESTROR antibody - 基因ID
- 2099
- UniProt
- P03372
- 途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
-
